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Cat. No.: HY-19287

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SQN400

Name: SQN400
Brand: MedChemExpress
SKU: HY-19287
Availability: PreOrder

(Synonyms: m-THPBC)

SQN400 (m-THPBC) is a near-infrared Photosensitizer and singlet oxygen-mediated photodynamic tissue necrosis inducer. SQN400 is activated by near-infrared light at a wavelength of 740 nm. SQN400 exhibits a dose threshold in photodynamic liver necrosis, beyond which the extent of necrosis correlates with the light product. SQN400 induces full-thickness necrosis in implanted mouse colorectal tumors. SQN400 is used in the study of colorectal adenocarcinoma.

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CAS No.: 122341-39-3
화학식: C₄₄H₃₄N₄O₄
분자량:682.78

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

SQN400 Chemical Structure

CAS No.: 122341-39-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

In Vivo

Anti-cancerOthers

Anti-cancer

SQN400 (1.2 mg/kg; i.v.; once; 24 h before irradiation) undergoes rapid in vivo photobleaching in Colo26 tumors in BALB/c mice and, in combination with 739 nm light, produces full-thickness tumor necrosis^[1].

Others

SQN400 (0.5 mg/kg; once; 24 h before irradiation) is optimally activated in normal Wistar rat liver under 738.9 nm near-infrared light^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (female adult)^[1]
Dosage:

1.2 mg/kg
Administration:

i.v. (tail vein); once; 24 h before irradiation
Result:

Bleached rapidly, with almost no photosensitizer fluorescence detectable from the tumor surface after 30 s of irradiation.
Showed an initial bleaching rate approximately 20 times greater than that of mTHPC under similar conditions.
Produced full-thickness tumor necrosis in all animals at 1.2 mg/kg with 3 J cm^-2 of 739 nm light 24 h after administration, with tumor thickness ranging from 3.7 to 5.0 mm.

Chemical Information

CAS No. 122341-39-3
분자량 682.78
화학식 C₄₄H₃₄N₄O₄
SMILES

OC1=CC=CC(=C1)C=2C3=CC=C(N3)C(C=4C=CC=C(O)C4)=C5N=C(C(C=6C=CC=C(O)C6)=C7C=CC(N7)=C(C=8C=CC=C(O)C8)C9=NC2CC9)CC5
Synonyms

m-THPBC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Rovers JP, et al. In vivo photodynamic characteristics of the near-infrared photosensitizer 5,10,15,20-tetrakis(M-hydroxyphenyl) bacteriochlorin. Photochemistry and photobiology. 2000 Sep;72(3):358-64.

[2]. Palumbo G, et al. Photodynamic therapy and cancer: a brief sightseeing tour. Expert opinion on drug delivery. 2007 Mar;4(2):131-48.

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100 mg

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