UMB68 sodium
UMB68 sodium is a selective GHB receptor ligand. UMB68 sodium displaces [3H]NCS-382 with an IC50 of 38 nM in rat cerebrocortical membranes. UMB68 sodium has no significant affinity at GABAB receptors, cannot be metabolized to GABA-active compounds.
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- CAS No.: 581099-89-0
- 화학식: C6H11NaO3
- 분자량:154.14
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
GHB receptor[1]
In Vitro
UMB68 inhibits [3H]NCS382 (16 nM) binding to the rat cerebrocortical membranes, with an IC50 of 38 nM compared with 25 μM for GHB[1].
UMB68 shows no affinity (IC50 >100 μM) at GABA(A) or GABA(B) receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male Sprague-Dawley rats (250-300 g) are carried out discrimination training[1]
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Dosage:320, 660, 1000, 1778 mg/kg
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Administration:I.p. injection
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Result:Caused vehicle-lever responding up to a dose (1778 mg/kg) that decreased markedly or eliminated lever pressing.
Chemical Information
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CAS No. 581099-89-0
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분자량 154.14
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화학식 C6H11NaO3
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SMILES
CC(C)(O)CCC(O[Na])=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UMB68 sodium Related Classifications
HY-135034 Related Classifications
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