VPC285785
VPC285785 is an orally active SARS-CoV-2 main protease inhibitor with an IC50 of 0.8 μM and a Kd of 2.7 μM. VPC285785 functionally inhibits the viral main protease-mediated processing of viral polyprotein precursors required for viral replication. VPC285785 reduces viral loads in the liver, brain and spleen tissues of MHV-infected mice. VPC285785 is applicable to the research of coronavirus infections.
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- CAS No.: 2759276-10-1
- 화학식: C24H25F2N5O3
- 분자량:469.48
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
VPC285785 (10 μM) exerts weak inhibitory effects on human cathepsin L (CatL), with only 15% inhibition observed at the concentration of 10 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Parmacokinetics
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/CJ (female, 8-10 weeks old, 18.5-26.5 g, intranasal infection with MHV-A59)[1]
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Dosage:150 mg/kg
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Administration:p.o.; once daily; 3 days (day 1, 2, 3 post-infection)
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Result:Reduced liver enzyme levels: alanine transaminase (ALT) 65.5 U/L, aspartate aminotransferase (AST) 126.0 U/L, and total protein (TP) 54.16 g/L.
Showed less pronounced decrease in blood urea nitrogen (BUN) levels.
Lowered white blood cell (WBC) counts.
Achieved statistically significant reduction in viral load in the liver, brain, and spleen; no significant differences in viral load observed in the lung, heart, or kidney.
Chemical Information
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CAS No. 2759276-10-1
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분자량 469.48
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화학식 C24H25F2N5O3
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SMILES
FC1=CC(F)=C(C=C(C(N2C[C@H](C3(C)C)[C@H]3[C@H]2C(N[C@H](C#N)C[C@@H]4CCNC4=O)=O)=O)N5)C5=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VPC285785 Related Classifications
HY-181983 Related Classifications
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