Zalypsis
Zalypsis (PM00104) has anti-tumor activity. Zalypsis binds to DNA and shows cytotoxicity. Zalypsis inhibits cell cycle and transcription, and leads to double stranded DNA breaks.
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- CAS No.: 308359-57-1
- 화학식: C37H38F3N3O8
- 분자량:709.71
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 308359-57-1
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분자량 709.71
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화학식 C37H38F3N3O8
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SMILES
O=C(NC[C@H]1C2=C3C(OCO3)=C(C)C(OC(C)=O)=C2C[C@]4([H])N1[C@@H](O)[C@@]5([H])N(C)[C@]4([H])C6=C(C5)C=C(C)C(OC)=C6O)/C=C/C7=CC(C(F)(F)F)=CC=C7
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Synonyms
PM00104
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Duan Z, et al. Diverse cross-resistance phenotype to ET-743 and PM00104 in multi-drug resistant cell lines. Cancer Chemother Pharmacol. 2009 May;63(6):1121-9. [Content Brief]
[2]. Petek BJ, et al. PM00104 (Zalypsis®): a marine derived alkylating agent. Molecules. 2014 Aug 15;19(8):12328-35. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Zalypsis Related Classifications
HY-16401 Related Classifications
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