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Cat. No.: HY-184715

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LasR-IN-6

LasR-IN-6 is a LasR inhibitor with an IC₅₀ of 0.261 μM, and exhibits antibacterial activity against Pseudomonas aeruginosa. LasR-IN-6 stably binds to the active site of LasR via hydrophobic interactions, disrupts receptor dimerization, and interferes with quorum sensing. LasR-IN-6 inhibits protease production, biofilm formation, twitching motility and swarming motility in Pseudomonas aeruginosa. LasR-IN-6 can be used in studies related to Pseudomonas aeruginosa infection.

For research use only. We do not sell to patients.

CAS No.: 872546-39-9
Formula: C₂₅H₁₉N₅O₅
Molecular Weight:469.45

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Please store the product under the recommended conditions in the Certificate of Analysis.

LasR-IN-6 Chemical Structure

CAS No.: 872546-39-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

LasR-IN-6 (compound 7d) exhibits antibacterial activity against Pseudomonas aeruginosa PAO1, with an MIC of 62.5 μg/mL^[1].
LasR-IN-6 (31.25 μg/mL; overnight) significantly inhibits protease production by Pseudomonas aeruginosa PAO1, with an inhibition rate of 70.4%^[1].
LasR-IN-6 (31.25 μg/mL; 24 h) significantly inhibits biofilm formation by Pseudomonas aeruginosa PAO1, with an inhibition rate of 79.4%^[1].
LasR-IN-6 (31.25 μg/mL; 48 h (twitching), 16 h (swarming)) inhibits twitching motility of Pseudomonas aeruginosa PAO1 by 57.9% and swarming motility by 74.7%^[1].
LasR-IN-6 forms a stable and energetically favorable complex with LasR, and repeatedly induces the dissociation of LasR dimers starting at approximately 175 ns, thereby disrupting the quorum sensing signaling pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 872546-39-9
Molecular Weight 469.45
Formula C₂₅H₁₉N₅O₅
SMILES

O=C(NC1=CC=C([N+]([O-])=O)C=C1)COC2=CC=C(/C=C(C3=NC4=CC=CC=C4N3)/C#N)C=C2OC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mohammed E Z, et al. Targeting quorum sensing in Pseudomonas aeruginosa: Novel benzo[d]imidazole-based LasR inhibitors with tunable head, α,β-unsaturated linker, and tail segments. Bioorganic Chemistry, 2026, 180: 110160.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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