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Cat. No.: HY-189090

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LEX-K02

LEX-K02 is a broad-spectrum and potent thiazole amide antifungal agent with an EC₅₀ of 0.140 μM. LEX-K02 inhibits fungal growth by disrupting the fungal cell membrane to cause leakage of intracellular substances and targeting the map00510 pathway to interfere with N-glycan biosynthesis. LEX-K02 can be used in studies related to Gaeumannomyces graminis infection.

For research use only. We do not sell to patients.

CAS No.: 3106140-37-5
Formula: C₂₈H₂₂F₄N₂O₃S
Molecular Weight:542.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LEX-K02 Chemical Structure

CAS No.: 3106140-37-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

LEX-K02 (0.05-100 μM; 24 h-7 days) potently inhibits mycelial growth of Gaeumannomyces graminis with an EC₅₀ of 0.140 μM. It disrupts cell membrane integrity, increases cell membrane permeability, causes leakage of cytoplasmic contents, alters gene expression and metabolite levels in Gaeumannomyces graminis, and significantly impairs the N-glycan biosynthesis pathway^[1].
LEX-K02 (6.25-100 μM) is safe for wheat; it exerts no adverse effects on seed germination or seedling growth at concentrations up to 100 μM, and exhibits a weak growth-promoting effect on roots and shoots^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3106140-37-5
Molecular Weight 542.54
Formula C₂₈H₂₂F₄N₂O₃S
SMILES

O=C(C1=CSC(C2=CC(F)=C(C=C2)F)=N1)N[C@@H](C)C(O[C@@H](C)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kong W, et al. Scaffold Hopping of Florylpicoxamid for Structurally and Biologically Distinct Antifungal Leads. Journal of agricultural and food chemistry. 2026 Aug 12;74(31):24149-24160.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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