Lipid A-11
Based on 1 Customer Validation
Lipid A-11 (Compound A-11) (CICL1) is an ionizable cationic lipid. Lipid A-11 can be used to prepare lipid nanoparticles. Lipid A-11 can be used in research involving T cell-targeted transfection.
For research use only. We do not sell to patients.
- Purity : 99.90%
- CAS No.: 2996998-09-3
- Formula: C55H100N2O14
- Molecular Weight:1013.39
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Lipid A-11 can be used to prepare lipid nanoparticles and can be used in research involving T cell-targeted transfection[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2996998-09-3
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Appearance Liquid (Density: 1.038±0.06 g/cm3)
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Molecular Weight 1013.39
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Formula C55H100N2O14
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Color Colorless to light yellow
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SMILES
O=C(N(CCOC(CC(COC(CCCCCCCC)=O)COC(CCCCCCCC)=O)=O)CCOC(CC(COC(CCCCCCCC)=O)COC(CCCCCCCC)=O)=O)OCCN(C)C
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Synonyms
CICL1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro:
Ethanol : ≥ 50 mg/mL (49.34 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Research Protocol for Cancer Immunology
Cancer immunology studies how the immune system recognizes, suppresses, edits, or fails to eliminate malignant cells through tumor antigen release, antigen presentation, T-cell priming, immune trafficking, tumor-cell killing, and feedback inhibition in the tumor microenvironment. The cancer-immunity cycle links tumor antigenicity, dendritic-cell priming, CD8+ T-cell infiltration, cytotoxic function, and immune-checkpoint regulation to tumor rejection or immune escape. Immune-checkpoint pathways such as PD-1/PD-L1 and CTLA-4 suppress antitumor T-cell activity and can be therapeutically blocked, but many tumors remain resistant because of poor antigen presentation, weak T-cell infiltration, suppressive myeloid cells, regulatory T cells, and tumor-intrinsic immune-exclusion programs. Unresolved questions include which immune-cell states predict response, how tumor-intrinsic pathways exclude immune cells, how myeloid suppression limits checkpoint blockade, and which combination strategies
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 0.9868 mL | 4.9339 mL | 9.8679 mL | 24.6697 mL |
| 5 mM | 0.1974 mL | 0.9868 mL | 1.9736 mL | 4.9339 mL | |
| 10 mM | 0.0987 mL | 0.4934 mL | 0.9868 mL | 2.4670 mL | |
| 15 mM | 0.0658 mL | 0.3289 mL | 0.6579 mL | 1.6446 mL | |
| 20 mM | 0.0493 mL | 0.2467 mL | 0.4934 mL | 1.2335 mL | |
| 25 mM | 0.0395 mL | 0.1974 mL | 0.3947 mL | 0.9868 mL | |
| 30 mM | 0.0329 mL | 0.1645 mL | 0.3289 mL | 0.8223 mL | |
| 40 mM | 0.0247 mL | 0.1233 mL | 0.2467 mL | 0.6167 mL |
Lipid A-11 Related Classifications
HY-170333 Related Classifications
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