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Cat. No.: HY-114550

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LY339434

LY339434 is a potent and selective agonist for the hydrochloride receptor GluR5. LY339434 affects the rapid death of neurons through n-methyl-D-aspartate (NMDA) receptors.

For research use only. We do not sell to patients.

CAS No.: 219566-62-8
Formula: C₁₈H₁₉NO₄
Molecular Weight:313.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

LY339434 Chemical Structure

CAS No.: 219566-62-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

LY339434 is a potent and selective agonist for the hydrochloride receptor GluR5. LY339434 affects the rapid death of neurons through n-methyl-D-aspartate (NMDA) receptors^[1]^[2].

All iGluR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	>100 μM Compound: LY-339434	Compound was tested for agonistic activity at Glutamate receptor 6 using HEK293 cells Compound was tested for agonistic activity at Glutamate receptor 6 using HEK293 cells	[PMID: 10969973]
HEK293	EC₅₀	>100 μM Compound: 32, LY-339434	Effective concentration against human GluR6 expressed in HEK293 cells Effective concentration against human GluR6 expressed in HEK293 cells	[PMID: 10821708]
HEK293	EC₅₀	0.8 μM Compound: 32, LY-339434	Effective concentration required for evoking response in HEK293 cell Effective concentration required for evoking response in HEK293 cell	[PMID: 10821708]
HEK293	EC₅₀	2.5 μM Compound: LY-339434	Compound was tested for agonistic activity at Glutamate receptor 5 using HEK293 cells Compound was tested for agonistic activity at Glutamate receptor 5 using HEK293 cells	[PMID: 10969973]
HEK293	EC₅₀	2.5 μM Compound: 32, LY-339434	Effective concentration against GluR5 expressed in HEK293 cells Effective concentration against GluR5 expressed in HEK293 cells	[PMID: 10821708]

In Vitro

LY339434 (1-1000 μM, 24 h) inhibits cortical neuronal cell activity in a concentration-dependent manner. EC₅₀ was 11.4 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 219566-62-8
Molecular Weight 313.35
Formula C₁₈H₁₉NO₄
SMILES

N[C@@H](C[C@@H](C/C=C/C1=CC=C2C=CC=CC2=C1)C(O)=O)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Small B, et al. LY339434, a GluR5 kainate receptor agonist. Neuropharmacology. 1998 Oct-Nov;37(10-11):1261-7. [Content Brief]

[2]. Moldrich RX, et al. Excitotoxic profile of LY339434, a GluR5 agonist, in cultured murine cortical neurons. Brain Res. 2000 Apr 17;862(1-2):270-5. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
Chemical Information
Purity & Documentation
References

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LY339434

All iGluR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

LY339434 Related Classifications

HY-114550 Related Classifications