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Cat. No.: HY-149611

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Lysyl hydroxylase 2-IN-2

Lysyl hydroxylase 2-IN-2 (compound 13) is a potent Lysyl hydroxylase 2 (LH2) inhibitor, with the IC₅₀ of approximately 500 nM. Lysyl hydroxylase 2-IN-2 inhibits the migration in 344SQ WT cells, but not impedes the migration of the same cell line with an LH2 knockout cells.

For research use only. We do not sell to patients.

Formula: C₁₉H₂₁N₃O₂
Molecular Weight:323.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Lysyl hydroxylase 2-IN-2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Monoamine Oxidase Isoforms :

MAO-A
MAO-B

Chemical Information

Molecular Weight 323.39
Formula C₁₉H₂₁N₃O₂
SMILES

O=C(C1=CC=CC(N2CCN(C)CC2)=C1)CC(C3=CC=NC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Molecular Biology Cell Biology

Gene Editing
Gene editing modify specific sites within the genome through gene deletions, insertions or conversions to study functionally unknown genes or conduct gene therapy. It is also used to change the biological traits of organisms to establish new varieties. Gene editing techniques include zinc finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas 9) (CRISPR/Cas9).
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Cell migration
Cell migration is a method that plays an important role in wound healing, cell differentiation, embryonic development, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Juhoon Lee, et al.Unleashing the Potential of 1,3-Diketone Analogues as Selective LH2 Inhibitors. ACS Med. Chem. Lett. 2023, 14, 10, 1396–1403

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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