MAO-B-IN-57
MAO-B-IN-57 is a selective MAO-B inhibitor with an IC50 of 41.38 nM against human MAO-B. MAO-B-IN-57 shows no significant in vitro cytotoxicity and can significantly increase the survival rate of PC12 cells damaged by 6-OHDA. MAO-B-IN-57 can be used in studies related to Parkinson's disease.
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- CAS No.: 1522345-35-2
- Formule: C15H13FO3
- Masse moléculaire:260.26
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
MAO-B 41.38 nM (IC50) |
MAO-A |
In Vitro
MAO-B-IN-57 (compound 5) (0.001-100 μM; 15 min) inhibits human MAO-A and human MAO-B enzymes, with an IC50 of > 100 μM against MAO-A and an IC50 of 431.38 nM against MAO-B, exhibiting a high MAO-B selectivity index[1].
MAO-B-IN-57 (20-100 μM; 24-72 h) exhibits low cytotoxicity in PC12 neuroblastoma cells[1].
MAO-B-IN-57 (20 μM; 1 h pre-treatment + 24 h co-incubation) increases the survival rate of PC12 cells damaged by 40 μM 6-OHDA, with a cytoprotective efficiency higher than 30%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1522345-35-2
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Masse moléculaire 260.26
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Formule C15H13FO3
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SMILES
O=C(C)C1=CC=C(C=C1O)OCC2=CC(F)=CC=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MAO-B-IN-57 Related Classifications
HY-183437 Related Classifications
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