MAO-B-IN-57

Cat. No.: HY-183437: Data Sheet Handling Instructions
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MAO-B-IN-57 is a selective MAO-B inhibitor with an IC₅₀ of 41.38 nM against human MAO-B. MAO-B-IN-57 shows no significant in vitro cytotoxicity and can significantly increase the survival rate of PC12 cells damaged by 6-OHDA. MAO-B-IN-57 can be used in studies related to Parkinson's disease.

For research use only. We do not sell to patients.

MAO-B-IN-57 Chemical Structure

CAS No. : 1522345-35-2

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MAO-A MAO-B

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

MAO-B

41.38 nM (IC₅₀)

MAO-A

In Vitro

MAO-B-IN-57 (compound 5) (0.001-100 μM; 15 min) inhibits human MAO-A and human MAO-B enzymes, with an IC₅₀ of > 100 μM against MAO-A and an IC₅₀ of 431.38 nM against MAO-B, exhibiting a high MAO-B selectivity index^[1].
MAO-B-IN-57 (20-100 μM; 24-72 h) exhibits low cytotoxicity in PC12 neuroblastoma cells^[1].
MAO-B-IN-57 (20 μM; 1 h pre-treatment + 24 h co-incubation) increases the survival rate of PC12 cells damaged by 40 μM 6-OHDA, with a cytoprotective efficiency higher than 30%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

260.26

Formula

C₁₅H₁₃FO₃

CAS No.

1522345-35-2

SMILES

O=C(C)C1=CC=C(C=C1O)OCC2=CC(F)=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang Z, et al.. Neuroprotective effects of benzyloxy substituted small molecule monoamine oxidase B inhibitors in Parkinson's disease. Bioorganic & medicinal chemistry. 2016 Nov 15;24(22):5929-5940. [Content Brief]

MAO-B-IN-57 Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-571522345-35-2Monoamine OxidaseMAOrotenonehuman MAO-Aparkinson’s disease6-OHDAhuman MAO-BhMAO-BPC12 cellsInhibitorinhibitorinhibit

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