MC-Val-Cit-PAB-duocarmycin chloride

Name: MC-Val-Cit-PAB-duocarmycin chloride
Brand: MedChemExpress
SKU: HY-128904
Rating: 4.5 (1 reviews)

Art. -Nr.: HY-128904 Reinheit: 99.04%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

MC-Val-Cit-PAB-duocarmycin chloride is a agent-linker conjugate for ADC with potent antitumor activity by using Duocarmycin (a DNA minor groove binding alkylating agent), linked via the ADC linker MC-Val-Cit-PAB.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

MC-Val-Cit-PAB-duocarmycin chloride Chemische Struktur

CAS. Nr. : 2055896-98-3

Größe	Verfügbarkeit	Menge
1 mg	Auf Lager	Estimated Time of Arrival: December 31
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Angebot einholen
100 mg	Angebot einholen

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Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE MC-Val-Cit-PAB-duocarmycin chloride

•J Cell Mol Med. 2025 Jun;29(12):e70665. [Abstract]

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle Drug-Linker Conjugates for ADC Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

Biologische Aktivität
Reinheit & Dokumentation
Verweise
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Beschreibung

IC₅₀ & Target

Duocarmycins

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

1055.05

Formel

C₅₄H₆₅Cl₂N₉O₉

CAS. Nr.

2055896-98-3

Appearance

Solid

Color

White to light yellow

SMILES

ClC[C@H]1C2=C(C=C(O)C3=CC=CC=C23)N(C(C4=CC5=CC(OCC[N+](C)(C)CC6=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN7C(C=CC7=O)=O)=O)=O)=O)C=C6)=CC=C5N4)=O)C1.[Cl-]

Versand

Shipping with dry ice.

Speicherung

-80°C, protect from light, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 100 mg/mL (94.78 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9478 mL	4.7391 mL	9.4782 mL
5 mM	0.1896 mL	0.9478 mL	1.8956 mL
10 mM	0.0948 mL	0.4739 mL	0.9478 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 99.04%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (247 KB) HNMR (399 KB) RP-HPLC (225 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119. [Content Brief]

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.9478 mL	4.7391 mL	9.4782 mL	23.6956 mL
	5 mM	0.1896 mL	0.9478 mL	1.8956 mL	4.7391 mL
	10 mM	0.0948 mL	0.4739 mL	0.9478 mL	2.3696 mL
	15 mM	0.0632 mL	0.3159 mL	0.6319 mL	1.5797 mL
	20 mM	0.0474 mL	0.2370 mL	0.4739 mL	1.1848 mL
	25 mM	0.0379 mL	0.1896 mL	0.3791 mL	0.9478 mL
	30 mM	0.0316 mL	0.1580 mL	0.3159 mL	0.7899 mL
	40 mM	0.0237 mL	0.1185 mL	0.2370 mL	0.5924 mL
	50 mM	0.0190 mL	0.0948 mL	0.1896 mL	0.4739 mL
	60 mM	0.0158 mL	0.0790 mL	0.1580 mL	0.3949 mL
	80 mM	0.0118 mL	0.0592 mL	0.1185 mL	0.2962 mL