2. Academic Validation
  3. In vivo efficacy of the diuretic agent ethacrynic acid against multiple myeloma

In vivo efficacy of the diuretic agent ethacrynic acid against multiple myeloma

  • Leuk Res. 2012 May;36(5):598-600. doi: 10.1016/j.leukres.2012.01.025.
Young Kim 1,  Sanna-Marie Gast,  Tomoyuki Endo,  Desheng Lu,  Dennis Carson,  Ingo G H Schmidt-Wolf
Affiliations

Affiliation

  • 1 Department of Internal Medicine III, Center for Integrated Oncology, University of Bonn, Bonn, Germany.
PMID: 22386728 DOI: 10.1016/j.leukres.2012.01.025
Abstract

It was recently confirmed that the diuretic agent ethacrynic acid (EA) inhibits Wnt/beta catenin signaling in myeloma. This study investigated the antitumor effect of EA in vivo in a murine myeloma model. In vivo, tumor growth was significantly reduced and overall survival significantly prolonged in mice treated with EA as compared to untreated mice. Interestingly, this effect was higher as compared to the effect by lenalidomide, a commonly used drug against myeloma. These results reveal a significant in vivo effect by EA against myeloma.

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