Alpinetin ameliorates inflammatory response in LPS-induced endometritis in mice

  • Int Immunopharmacol. 2018 Sep:62:309-312. doi: 10.1016/j.intimp.2018.07.010.
Yuanjiao Liang  1 ,  Tao Shen  2 ,  Qi Ming  2 ,  Guoqing Han  2 ,  Yan Zhang  2 ,  Jinlan Liang  2 ,  Duanrong Zhu  3
Affiliations
  • 1. Reproductive Medicine Center, Zhongda Hospital, Southeast University, Jiangsu, Nanjing 210009, China. Electronic address: [email protected].
  • 2. Reproductive Medicine Center, Zhongda Hospital, Southeast University, Jiangsu, Nanjing 210009, China.
  • 3. The Department of Gynecology and Obstetrics, Jinling Hospital, Medical School of Nanjing University, Jiangsu, Nanjing 210002, China.
PMID: 30048861 DOI: 10.1016/j.intimp.2018.07.010
Abstract

Alpinetin has been reported to have anti-inflammatory effects. However, whether alpinetin has anti-inflammatory effects in LPS-induced endometritis has not been thoroughly elucidated to date. The aim of this study was to investigate the protective effects of alpinetin on LPS-induced endometritis in mice. A mouse model of endometritis was induced by LPS and alpinetin was given 1 h before LPS treatment. According to the results, alpinetin protected mice against LPS-induced endometritis by attenuating uterine histological changes and myeloperoxidase (MPO) activity. The LPS-induced inflammatory response was inhibited by alpinetin as confirmed by the inhibition of TNF-α, IL-1ß, and IL-6 production. Furthermore, LPS-induced TLR4 expression and NF-κB activation were significantly suppressed by alpinetin. In addition, the expression of PPAR-γ was dose-dependently increased by the treatment of alpinetin. Taken together, the results of this study showed that alpinetin had protective effects against LPS-induced endometritis in mice, and the beneficial effects were occurred through the activation of PPAR-γ and inhibition of the TLR4 signaling pathway.

Keywords
Alpinetin; Endometritis; LPS; PPAR-γ.
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