Mebeverine acid-d₅ hydrochloride  (Synonyms: Mebeverine metabolite Mebeverine acid-d5 hydrochloride)

Mebeverine acid-d₅ (Mebeverine metabolite Mebeverine acid-d₅) hydrochloride is deuterium labeled Mebeverine acid hydrochloride. Mebeverine acid hydrochloride is a secondary metabolite of the intestinal antispasmodic agent Mebeverine (HY-A0078). Mebeverine acid hydrochloride is generated by the hydrolysis of Mebeverine in the body and is considered a key circulating metabolite. Mebeverine acid hydrochloride is an important marker for oral Mebeverine.

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

320.87

C₁₆H₂₁D₅ClNO₃

475203-77-1

Solid

White to off-white

CC(N(C([2H])([2H])C([2H])([2H])[2H])CCCC(O)=O)CC1=CC=C(OC)C=C1.Cl

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]