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Cat. No.: HY-157750

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MEK1/C-Raf-IN-1

MEK1/C-Raf-IN-1 (Compound 14d) is a MEK1/C-Raf inhibitor with IC₅₀ values of 97 and 23 nM, respectively. MEK1/C-Raf-IN-1 has antitumor activity.

For research use only. We do not sell to patients.

CAS No.: 946128-76-3
Formula: C₂₂H₁₉FN₄O₅S
Molecular Weight:470.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

MEK1/C-Raf-IN-1 Chemical Structure

CAS No.: 946128-76-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

MEK1/C-Raf-IN-1 (Compound 14d) is a MEK1/C-Raf inhibitor with IC₅₀ values of 97 and 23 nM, respectively. MEK1/C-Raf-IN-1 has antitumor activity^[1].

All MEK Isoforms :

All Raf Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	1.9 μM Compound: 14d	Antiproliferative activity against human A-375 cells incubated for 4 days by MTT assay Antiproliferative activity against human A-375 cells incubated for 4 days by MTT assay	[PMID: 36655129]
C32	ED₅₀	1.44 mg/kg Compound: 14	Antitumor activity against human C32 cells xenografted in po dosed BALB-nu/nu mouse assessed as tumor growth inhibition administered qd for 11 days Antitumor activity against human C32 cells xenografted in po dosed BALB-nu/nu mouse assessed as tumor growth inhibition administered qd for 11 days	[PMID: 24900832]
C32	IC₅₀	57 nM Compound: 14	Growth inhibition of human C32 cells harboring R-Raf V600E mutant Growth inhibition of human C32 cells harboring R-Raf V600E mutant	[PMID: 24900832]
HCT-116	IC₅₀	17 nM Compound: 14	Inhibition of human HCT116 cell growth after 96 hrs by counting kit-8 analysis Inhibition of human HCT116 cell growth after 96 hrs by counting kit-8 analysis	[PMID: 24900832]
HCT-116	IC₅₀	17 nM Compound: 14d	Antiproliferative activity against human HCT116 cells assessed as cell viability after 96 hrs by cell counting kit-8 assay Antiproliferative activity against human HCT116 cells assessed as cell viability after 96 hrs by cell counting kit-8 assay	[PMID: 24900605]

Chemical Information

CAS No. 946128-76-3
Molecular Weight 470.47
Formula C₂₂H₁₉FN₄O₅S
SMILES

O=C1OC2=C(C(C)=C1CC3=C(F)C(NS(=O)(NC)=O)=CC=C3)C=CC(OC4=NC=CC=N4)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hyohdoh I, et al. Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties. ACS Med Chem Lett. 2013 Sep 22;4(11):1059-63. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Chemical Information
Purity & Documentation
References

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MEK1/C-Raf-IN-1

All MEK Isoforms

All Raf Isoforms