MenA-IN-1
MenA IN-1 is an effective inhibitor of 1,4-dihydroxy-2-naphthoate isoprenyltransferase (MenA) from Mycobacterium tuberculosis (MTB) with an IC50 value of 13 µM and an GIC50 value of 8 µM. MenA IN-1 can be used to curb the continuous spread of tuberculosis.
For research use only. We do not sell to patients.
- CAS No.: 3041997-97-8
- Formula: C29H36N2O2
- Molecular Weight:444.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: 13 µM (1,4-dihydroxy-2-naphthoate isoprenyltransferase, MenA)[1]
In Vitro
MenA IN-1 (compound 2) (50 µM) has bactericidal effect on Mycobacterium tuberculosis (MTB) and significantly enhances the bactericidal effect when combined with Q203 (HY-101040) or IMP (HY-108213)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 3041997-97-8
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Molecular Weight 444.61
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Formula C29H36N2O2
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SMILES
CCCN(C1=CC=C(C=C1)CN2CCC(CC2)COC3=CC(OC4=CC=CC=C4)=CC=C3)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MenA-IN-1 Related Classifications
HY-152495 Related Classifications
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