Methylstenbolone
Methylstenbolone is a steroid and an anti-inflammatory agent. Methylstenbolone inhibits nitric oxide production in macrophages and exhibits cytotoxicity against breast cancer cells and normal fibroblasts. Methylstenbolone can be used for the research of inflammation and breast cancer.
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- CAS No.: 6176-38-1
- Formule: C21H32O2
- Masse moléculaire:316.48
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Methylstenbolone (1-25 μg/mL) potently inhibits nitric oxide production in J774.2 mouse macrophage cells with an IC50 of 10.1 μg/mL[3].
Methylstenbolone (6.25-50 µM; 48 h) is cytotoxic to MCF-7 human breast cancer cells (IC50 = 12.26 μg/mL) and toxic to BJ human fibroblast normal cells (IC50 = 8.69 μg/mL), but shows no cytotoxicity in NCI-H460 human lung cancer cells or HeLa human cervical cancer cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7, NCI-H460, HeLa, BJ human fibroblast normal cells
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Concentration:6.25, 12.5, 25, 50 µM
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Incubation Time:48 h
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Result:Exhibited cytotoxicity against MCF-7 breast cancer cells with an IC50 of 12.26 μg/mL.
Showed toxicity toward non-cancerous BJ human fibroblast cells with an IC50 of 8.69 μg/mL.
Showed no cytotoxicity in NCI-H460 human lung cancer cells or HeLa human cervical cancer cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:uPA+/+-SCID chimeric mice transplanted with primary human hepatocytes[1]
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Dosage:1 mg
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Administration:i.g.; single dose
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Result:Detected no parent methylstenbolone compound and metabolites U1-U10, U13 in chimeric mouse urine.
Detected two dihydroxylated metabolites (U11 and U12) in both chimeric and nonchimeric mouse urine.
Chemical Information
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CAS No. 6176-38-1
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Masse moléculaire 316.48
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Formule C21H32O2
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SMILES
CC1=C[C@]2([C@H](CC1=O)CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@]4(O)C)C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Geldof L, et al. Metabolism of methylstenbolone studied with human liver microsomes and the uPA⁺/⁺-SCID chimeric mouse model. Biomed Chromatogr. 2014;28(7):974-985. [Content Brief]
[2]. Piper T, et al. Studies on the in vivo metabolism of methylstenbolone and detection of novel long term metabolites for doping control analysis. Drug Test Anal. 2019;11(11-12):1644-1655. [Content Brief]
[3]. Aamer M, et al. New anti-inflammatory and non-cytotoxic metabolites of methylstenbolone obtained by microbial transformation. Bioorg Chem. 2022;129:106187. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Methylstenbolone Related Classifications
HY-W743094 Related Classifications
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- Methylstenbolone
- 6176-38-1
- Drug Derivative
- BJ human fibroblast normal cells
- normal fibroblasts
- macrophages
- MCF-7 human breast cancer cells
- J774.2 mouse macrophage cells
- breast cancer cells
- human liver microsomes
- chimeric mouse urine
- NCI-H460 human lung cancer cells
- HeLa human cervical cancer cells
- Inhibitor
- inhibitor
- inhibit