2. PROTAC
  3. PROTACs
  4. MI-389

MI-389 is a PROTAC translation termination factor GSPT1 degrader. MI-389 disrupts a target that is a shared dependency in different AML and ALL cell lines, and that MI-389 action is dependent on the CRL4CRBN E3 ligase.

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MI-389

MI-389 構造式

CAS 番号 : 2222635-92-7

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 519 在庫あり
Solution
10 mM * 1 mL in DMSO USD 519 在庫あり
Solid
5 mg $360 在庫あり
10 mg $580 在庫あり
25 mg $1160 在庫あり
50 mg $1860 在庫あり
100 mg $2980 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

MI-389 関連抗体

Top Publications Citing Use of Products

PROTACs アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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  • 純度とドキュメンテーション

  • 参考文献

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製品説明

MI-389 is a PROTAC translation termination factor GSPT1 degrader. MI-389 disrupts a target that is a shared dependency in different AML and ALL cell lines, and that MI-389 action is dependent on the CRL4CRBN E3 ligase[1].

IC50 & Target[1]

Cereblon

 

Cellular Effect
Cell Line Type Value Description References
Kasumi 1 EC50
21.3 nM
Compound: 18; MI-389
Antiproliferative activity against human Kasumi 1 cells assessed as reduction in cell viability incubated for 72 hrs by Cell-titer glo luminescent assay
Antiproliferative activity against human Kasumi 1 cells assessed as reduction in cell viability incubated for 72 hrs by Cell-titer glo luminescent assay
[PMID: 39094274]
分子量

654.69

分子式

C35H35FN6O6
CAS 番号
Appearance

Solid

Color

Yellow to orange

SMILES

O=C1C2=C(NCCCCCCNC(C3=C(C)NC(/C=C4C5=CC(F)=CC=C5NC/4=O)=C3C)=O)C=CC=C2C(N1C6C(NC(CC6)=O)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶剤 & 溶解度
体外: 

DMSO : 66.67 mg/mL (101.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5274 mL 7.6372 mL 15.2744 mL
5 mM 0.3055 mL 1.5274 mL 3.0549 mL
10 mM 0.1527 mL 0.7637 mL 1.5274 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

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濃度 （終了）

C2

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体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5274 mL 7.6372 mL 15.2744 mL 38.1860 mL
5 mM 0.3055 mL 1.5274 mL 3.0549 mL 7.6372 mL
10 mM 0.1527 mL 0.7637 mL 1.5274 mL 3.8186 mL
15 mM 0.1018 mL 0.5091 mL 1.0183 mL 2.5457 mL
20 mM 0.0764 mL 0.3819 mL 0.7637 mL 1.9093 mL
25 mM 0.0611 mL 0.3055 mL 0.6110 mL 1.5274 mL
30 mM 0.0509 mL 0.2546 mL 0.5091 mL 1.2729 mL
40 mM 0.0382 mL 0.1909 mL 0.3819 mL 0.9547 mL
50 mM 0.0305 mL 0.1527 mL 0.3055 mL 0.7637 mL
60 mM 0.0255 mL 0.1273 mL 0.2546 mL 0.6364 mL
80 mM 0.0191 mL 0.0955 mL 0.1909 mL 0.4773 mL
100 mM 0.0153 mL 0.0764 mL 0.1527 mL 0.3819 mL
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MI-389 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MI-3892222635-92-7MI389MI 389PROTACsPROTACtranslation termination factorGSPT1CRL4CRBNInhibitorinhibitorinhibit

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製品名:
MI-389
製品番号:
HY-136688
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