ZXH-1-161
Based on 1 Customer Validation
ZXH-1-161 is a potent CRBN modulator that selectively induces the degradation of GSPT1 in a CRBN-dependent manner. ZXH-1-161 can inhibit the proliferation of multiple myeloma cells and exhibits antitumor activity.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 98.43%
- CAS No.: 2407654-51-5
- 화학식: C26H24N6O3
- 분자량:468.51
-
보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
용액&용해도
- Protocol
- 순도&문서
- References
-
Help & FAQs
-
HY-101488
CC-885CRBN Modulator/GSPT1 Molecular Glue Degrader -
HY-137206
ALV2Helios Degrader -
HY-132199
SJ6986GSPT1/2 Molecular Glue Degrader -
HY-130800
EragidomideGSPT1 Molecular Glue Degrader -
HY-146237
GolcadomideCereblon Modulator -
HY-A0003
LenalidomideImmunomodulator -
HY-129395
MezigdomideCereblon E3 Ubiquitin Ligase Modulating Agent -
HY-159646
BMS-986397CK1α Molecular Glue -
HY-153356
MRT-2359GSPT1 Molecular Glue Degrader -
HY-100947
VH-298VHL:HIF-α Interaction Inhibitor -
HY-157334
DEG-77IKZF2/CK1α Molecular Gel -
HY-120217
VH032VHL Ligand
All Eukaryotic Release Factor (eRF) Isoforms
More
Biological Activity
제품 설명
IC50 & Target
[1]|
eRF3a/GSPT1 |
In Vitro
ZXH-1-161 (0-50 μM; 48 h) exhibits CRBN-dependent antiproliferative activity in MM1.S wild-type cells with an IC50 of 0.039 µM[1].
ZXH-1-161 (0.01-10 µM; 4 h) can induce the degradation of GSPT1 in MM1.S cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MM1.S cells
-
Concentration:0.01, 0.1, 1 and 10 µM
-
Incubation Time:4 h
-
Result:Reduced the levels of GSPT1 in a dose-dependent manner.
Chemical Information
-
CAS No. 2407654-51-5
-
Appearance Solid
-
분자량 468.51
-
화학식 C26H24N6O3
-
Color White to off-white
-
SMILES
O=C1NC(C(CC1)N2C(C3=C(C2)C(NC4=NC(NC5=CC=C6C(CCC6)=C5)=NC=C4)=CC=C3)=O)=O
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
In Vitro:
DMSO : 250 mg/mL (533.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
순도&문서
-
Data Sheet (280 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1344 mL | 10.6721 mL | 21.3443 mL | 53.3607 mL |
| 5 mM | 0.4269 mL | 2.1344 mL | 4.2689 mL | 10.6721 mL | |
| 10 mM | 0.2134 mL | 1.0672 mL | 2.1344 mL | 5.3361 mL | |
| 15 mM | 0.1423 mL | 0.7115 mL | 1.4230 mL | 3.5574 mL | |
| 20 mM | 0.1067 mL | 0.5336 mL | 1.0672 mL | 2.6680 mL | |
| 25 mM | 0.0854 mL | 0.4269 mL | 0.8538 mL | 2.1344 mL | |
| 30 mM | 0.0711 mL | 0.3557 mL | 0.7115 mL | 1.7787 mL | |
| 40 mM | 0.0534 mL | 0.2668 mL | 0.5336 mL | 1.3340 mL | |
| 50 mM | 0.0427 mL | 0.2134 mL | 0.4269 mL | 1.0672 mL | |
| 60 mM | 0.0356 mL | 0.1779 mL | 0.3557 mL | 0.8893 mL | |
| 80 mM | 0.0267 mL | 0.1334 mL | 0.2668 mL | 0.6670 mL | |
| 100 mM | 0.0213 mL | 0.1067 mL | 0.2134 mL | 0.5336 mL |
ZXH-1-161 Related Classifications
HY-147158 Related Classifications
Powered by Bioz