ZXH-1-161
Based on 1 Customer Validation
ZXH-1-161 is a potent CRBN modulator that selectively induces the degradation of GSPT1 in a CRBN-dependent manner. ZXH-1-161 can inhibit the proliferation of multiple myeloma cells and exhibits antitumor activity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.43%
- CAS 番号: 2407654-51-5
- 分子式: C26H24N6O3
- 分子量:468.51
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
IC50 & Target
[1]|
eRF3a/GSPT1 |
体外実験
ZXH-1-161 (0-50 μM; 48 h) exhibits CRBN-dependent antiproliferative activity in MM1.S wild-type cells with an IC50 of 0.039 µM[1].
ZXH-1-161 (0.01-10 µM; 4 h) can induce the degradation of GSPT1 in MM1.S cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MM1.S cells
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Concentration:0.01, 0.1, 1 and 10 µM
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Incubation Time:4 h
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Result:Reduced the levels of GSPT1 in a dose-dependent manner.
化学情報
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CAS 番号 2407654-51-5
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性状 Solid
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分子量 468.51
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分子式 C26H24N6O3
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Color White to off-white
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SMILES
O=C1NC(C(CC1)N2C(C3=C(C2)C(NC4=NC(NC5=CC=C6C(CCC6)=C5)=NC=C4)=CC=C3)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 250 mg/mL (533.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (280 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1344 mL | 10.6721 mL | 21.3443 mL | 53.3607 mL |
| 5 mM | 0.4269 mL | 2.1344 mL | 4.2689 mL | 10.6721 mL | |
| 10 mM | 0.2134 mL | 1.0672 mL | 2.1344 mL | 5.3361 mL | |
| 15 mM | 0.1423 mL | 0.7115 mL | 1.4230 mL | 3.5574 mL | |
| 20 mM | 0.1067 mL | 0.5336 mL | 1.0672 mL | 2.6680 mL | |
| 25 mM | 0.0854 mL | 0.4269 mL | 0.8538 mL | 2.1344 mL | |
| 30 mM | 0.0711 mL | 0.3557 mL | 0.7115 mL | 1.7787 mL | |
| 40 mM | 0.0534 mL | 0.2668 mL | 0.5336 mL | 1.3340 mL | |
| 50 mM | 0.0427 mL | 0.2134 mL | 0.4269 mL | 1.0672 mL | |
| 60 mM | 0.0356 mL | 0.1779 mL | 0.3557 mL | 0.8893 mL | |
| 80 mM | 0.0267 mL | 0.1334 mL | 0.2668 mL | 0.6670 mL | |
| 100 mM | 0.0213 mL | 0.1067 mL | 0.2134 mL | 0.5336 mL |
ZXH-1-161 関連分類
HY-147158 関連分類
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