MK-8245 Trifluoroacetate
Based on 4 publication(s) in Google Scholar
MK-8245 Trifluoroacetate is a potent, liver-targeted stearoyl-CoA desaturase (SCD) inhibitor, with IC50s of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with antidiabetic and antidyslipidemic efficacy.
For research use only. We do not sell to patients.
- Purity : 98.45%
- CAS No.: 1415559-41-9
- Formula: C19H17BrF4N6O6
- Molecular Weight:581.27
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) MK-8245 Trifluoroacetate
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Biological Activity
Description
IC50 & Target
IC50: 1 nM (human SCD1), 3 nM (rat SCD1), 3 nM (mouse SCD1)[1]
In Vitro
MK-8245 Trifluoroacetate is a potent and liver-specific SCD inhibitor[1].
MK-8245 Trifluoroacetate displays similar potencies against human, rat and mouse SCD1, with IC50 values of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1[1].
MK-8245 Trifluoroacetate exhibits a significant SCD inhibition in the rat hepatocyte assay which contains functional, actives organic anion transporting polypeptides (OATPs) with IC50 of 68 nM, while being only weakly active OATPs in the HepG2 cell assay which is devoid of active with IC50 of ~1 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MK-8245 Trifluoroacetate improves glucose clearance in a dose-dependent manner in eDIO mice administrated before the glucose challenge[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL6 mice, male Sprague-Dawley rats[1]
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Dosage:10mg/kg
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Administration:Oral administration
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Result:Exhibits a tissue distribution profile concentrated in the liver.
Chemical Information
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CAS No. 1415559-41-9
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Appearance Solid
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Molecular Weight 581.27
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Formula C19H17BrF4N6O6
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Color Light yellow to yellow
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SMILES
O=C(CN1N=C(N=N1)C2=CC(N3CCC(CC3)OC4=CC(F)=CC=C4Br)=NO2)O.FC(C(O)=O)(F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (4)
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Journal Impact Factor
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Most Recent
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Sci China Life Sci
2022 Feb;65(2):341-361. PMID: 34047913 -
Neurosci Bull
2025 Jun 28. PMID: 40580390 -
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Elife
Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 ( Adgrf1). [Abstract]2023 Aug 15:12:e85131. PMID: 37580962
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MK-8245 Trifluoroacetate Related Classifications
HY-13077 Related Classifications
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