MLL1-IN-1 

MLL1-IN-1 is an orally active MLL1 inhibitor with an IC₅₀ of 0.043 μM. MLL1-IN-1 induces Menin protein degradation and inhibits the proliferation of leukemia cells. MLL1-IN-1 can induce tumor regression in leukemia-bearing mice. MLL1-IN-1 is useful for research into MLL1-associated leukemia^[1].

MLL1-IN-1 (7 days) inhibits the viability of MOLM-13, MV-4-11, and OCI-AML3 cells, with IC₅₀ values ​​of 0.04, 0.035, and 0.047 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MLL1-IN-1 (30-200 mg/kg, p.o., twice daily for 14 days) induces tumor regression in an MV-4-11 subcutaneous xenograft mouse model^[1].
MLL1-IN-1 (30-200 mg/kg, p.o., once daily for 21/90 days) induces tumor regression in a MOLM-13 subcutaneous xenograft mouse model^[1].
MLL1-IN-1 (150 mg/kg, p.o., once daily for 21 days) prolongs survival in an MLL-r AML patient-derived xenograft (PDX) mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

589.74

C₃₄H₄₄FN₅O₃

3058433-50-1

FC1=CC=[C@]([N@]2C(C=NC=C3)=C3C(C(C4CCN(C([C@@H]5CCC(C)(C)N5)=O)CC4)=O)=C2C)C(C(N(C(C)C)C(C)C)=O)=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Dedong Wu, et al. Solid-state forms of ((s)-2-(3-(1-(5,5-dimethylpyrrolidine-2-carbonyl)piperidine-4-carbonyl)-2-methyl-1h-pyrrolo[2,3-c]-pyridin-1-yl)-5-fluoro-n,n-diisopropylbenzamide salts. WO2026062248A1. 2026-03-26.