MLL1-IN-1
MLL1-IN-1 is an orally active MLL1 inhibitor with an IC50 of 0.043 μM. MLL1-IN-1 induces Menin protein degradation and inhibits the proliferation of leukemia cells. MLL1-IN-1 can induce tumor regression in leukemia-bearing mice. MLL1-IN-1 is useful for research into MLL1-associated leukemia.
For research use only. We do not sell to patients.
- CAS No.: 3058433-50-1
- Formula: C34H44FN5O3
- Molecular Weight:589.74
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Histone Methyltransferase Isoforms
More
Biological Activity
MLL1-IN-1 (7 days) inhibits the viability of MOLM-13, MV-4-11, and OCI-AML3 cells, with IC50 values of 0.04, 0.035, and 0.047 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MLL1-IN-1 (30-200 mg/kg, p.o., once daily for 21/90 days) induces tumor regression in a MOLM-13 subcutaneous xenograft mouse model[1].
MLL1-IN-1 (150 mg/kg, p.o., once daily for 21 days) prolongs survival in an MLL-r AML patient-derived xenograft (PDX) mouse model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Female CB17 SCID mice with MV-4-11 subcutaneous xenograft[1]
-
Dosage:30, 100, 200 mg/kg
-
Administration:p.o., twice daily for 14 days
-
Result:Reduced tumors by 88%, with a 100% recurrence rate following drug discontinuation at a dose of 30 mg/kg. Reduced tumors by 97%/99%, with no recurrence observed 6 weeks after drug discontinuation at doses of 100/200 mg/kg.
Chemical Information
-
CAS No. 3058433-50-1
-
Molecular Weight 589.74
-
Formula C34H44FN5O3
-
SMILES
FC1=CC=[C@]([N@]2C(C=NC=C3)=C3C(C(C4CCN(C([C@@H]5CCC(C)(C)N5)=O)CC4)=O)=C2C)C(C(N(C(C)C)C(C)C)=O)=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MLL1-IN-1 Related Classifications
HY-182793 Related Classifications
Powered by Bioz