1. Anti-infection
  2. SARS-CoV
  3. MMT5-14

MMT5-14 

Cat. No.: HY-151265
Handling Instructions

MMT5-14 is a remdesivir analogue with a higher antiviral activity in four variants of SARS-CoV-2 than Remdesivir (HY-104077). MMT5-14 inhibits SARS-CoV-2, α, β, γ and δ variants with EC50s of 0.4, 2.5, 15.9, 1.7 and 5.6 μM, respectively. MMT5-14 can be used for the research of COVID-19.

For research use only. We do not sell to patients.

MMT5-14 Chemical Structure

MMT5-14 Chemical Structure

CAS No. : 2719679-31-7

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Description

MMT5-14 is a remdesivir analogue with a higher antiviral activity in four variants of SARS-CoV-2 than Remdesivir (HY-104077). MMT5-14 inhibits SARS-CoV-2, α, β, γ and δ variants with EC50s of 0.4, 2.5, 15.9, 1.7 and 5.6 μM, respectively. MMT5-14 can be used for the research of COVID-19[1].

In Vitro

MMT5-14 (10 μM; 0-12 h) increases epithelial cell uptake[1].
MMT5-14 (5 μM; 2 d) shows a better in vitro antiviral activity than remdesivir[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Vero-E6 cell line
Concentration: 5 μM
Incubation Time: 2 days
Result: Inhibited SARS-CoV-2, alpha, beta, gamma and delta variants with EC50s of 0.4, 2.5, 15.9, 1.7 and 5.6 μM, respectively.
In Vivo

MMT5-14 (10 mg/kg; i.v. once) shows a higher stability than remdesivir in microsomes, and shows higher concentrations of prodrugs and active metabolites (NTP) in blood and lungs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Catheterized female hamsters[1]
Dosage: 10 mg/kg
Administration: Intravenous injection; 10 mg/kg once
Result: Showed higher intact prodrugs concentration than remdesivir in lungs after 4 hours injection, increased tissue exposure in most of the tissues and showed 5- to 10-fold higher tissue selectivity in lungs compared to remdesivir.
Molecular Weight

766.86

Formula

C39H55N6O8P

CAS No.
SMILES

C[[email protected]@H](C(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)NP(OC1=CC=CC=C1)(OC[[email protected]]2O[[email protected]@](C#N)(C3=CC=C4C(N)=NC=NN43)[[email protected]](O)[[email protected]@H]2O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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