2. Metabolic Enzyme/Protease
  3. Isocitrate Dehydrogenase (IDH)
  4. MRK-A

MRK-A is a selective, blood-brain-barrier permeable mutant IDH1 inhibitor with an IC50 value of 5 nM. MRK-A inhibits 2-HG production. MRK-A has anti-cancer activity against brain tumors.

For research use only. We do not sell to patients.

MRK-A

MRK-A Chemical Structure

CAS No. : 1934301-68-4

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MRK-A Related Antibodies

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Description

MRK-A is a selective, blood-brain-barrier permeable mutant IDH1 inhibitor with an IC50 value of 5 nM. MRK-A inhibits 2-HG production. MRK-A has anti-cancer activity against brain tumors[1].

IC50 & Target

IC50: 5 nM (mutant IDH1)[1]
Cellular Effect
Cell Line Type Value Description References
MOG-G-UVW IC50
43 nM
Compound: MRK-A
Antiproliferative activity against human MOG-G-UVW cells assessed as inhibition of cell proliferation incubated for 72 hrs by cell titer-Glo assay
Antiproliferative activity against human MOG-G-UVW cells assessed as inhibition of cell proliferation incubated for 72 hrs by cell titer-Glo assay
[PMID: 35450359]
Molecular Weight

454.56

Formula

C28H30N4O2
CAS No.
SMILES

O=C(N1CC2=CC=CN=C2NC3=CC=C(N4CCOCC4)C=C13)C5CCC6=CC=CC=C6CC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MRK-A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRK-A1934301-68-4Isocitrate Dehydrogenase (IDH)BT142U87MGGBMgliomaInhibitorinhibitorinhibit

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