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Cat. No.: HY-120422

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N-Desmethyl Regorafenib

N-Desmethyl Regorafenib is a demethylated metabolite of Regorafenib (HY-10331), formed by N-demethylation, and is found in feces and occasionally in plasma as a trace component. N-Desmethyl Regorafenib is a substrate for amide hydrolysis.

For research use only. We do not sell to patients.

CAS No.: 1343498-72-5
Formula: C₂₀H₁₃ClF₄N₄O₃
Molecular Weight:468.79

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

N-Desmethyl Regorafenib Chemical Structure

CAS No.: 1343498-72-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

N-Desmethyl Regorafenib (M-4) is a substrate for amide hydrolysis, leading to the formation of the carboxylic acid metabolite M-6^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

CAS No. 1343498-72-5
Molecular Weight 468.79
Formula C₂₀H₁₃ClF₄N₄O₃
SMILES

O=C(N)C1=NC=CC(OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C(F)=C2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gerisch M, et al. Mass balance, metabolic disposition, and pharmacokinetics of a single oral dose of regorafenib in healthy human subjects. Cancer chemotherapy and pharmacology. 2018 Jan;81(1):195-206.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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