Nampt activator-2

Name: Nampt activator-2
Brand: MedChemExpress
SKU: HY-148822
Rating: 4.5 (0 reviews)

Cat. No.: HY-148822 Purity: 98.79%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Nampt activator-2 (compound 34) is a potent NAMPT activator, with EC₅₀ of 0.023 μM. Nampt activator-2 shows moderate activity against CYP2C9 (0.060 μM), 2D6 (0.41 μM) and 2C19 (0.59 μM).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Nampt activator-2 화학구조

CAS No. : 2237268-90-3

사이즈	재고	수량

무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vitro

Nampt activator-2 (compound 34) (10 μM, 4 h) results in a marked increase of both NMN and NAD in A549 lung epithelial cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Nampt activator-2 (compound 34) (1 mg/kg iv and 10 mg/kg po, once) shows low plasma clearance, good exposure and excellent oral bioavailability (%F = 80)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mouse^[1]

Dosage:

1 mg/kg iv and 10 mg/kg po

Administration:

IV, PO; once (Pharmacokinetic Analysis)

Result:

Pharmacokinetic Parameters of Nampt activator-2 in mouse^[1].

	IV (1 mg/kg)	PO (10 mg/kg)
C_max (ng/mL)		9550
AUC_0-24 (ng/mL∗h)		54463
t_1/2 (h)		3.2
CL (mL/min/kg)	3
Vd (L/kg)	0.61
F (%)		80

분자량

390.84

화학식

C₁₇H₁₅ClN₄O₃S

CAS No.

2237268-90-3

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NCC1=CNN=C1)NC2=CC=C(S(=O)(C3=CC=C(C=C3)Cl)=O)C=C2

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 250 mg/mL (639.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5586 mL	12.7930 mL	25.5859 mL
5 mM	0.5117 mL	2.5586 mL	5.1172 mL
10 mM	0.2559 mL	1.2793 mL	2.5586 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 98.79%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (247 KB) HNMR (282 KB) RP-HPLC (249 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Pinkerton AB, et al. Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators. Bioorg Med Chem Lett. 2021 Jun 1;41:128007. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5586 mL	12.7930 mL	25.5859 mL	63.9648 mL
	5 mM	0.5117 mL	2.5586 mL	5.1172 mL	12.7930 mL
	10 mM	0.2559 mL	1.2793 mL	2.5586 mL	6.3965 mL
	15 mM	0.1706 mL	0.8529 mL	1.7057 mL	4.2643 mL
	20 mM	0.1279 mL	0.6396 mL	1.2793 mL	3.1982 mL
	25 mM	0.1023 mL	0.5117 mL	1.0234 mL	2.5586 mL
	30 mM	0.0853 mL	0.4264 mL	0.8529 mL	2.1322 mL
	40 mM	0.0640 mL	0.3198 mL	0.6396 mL	1.5991 mL
	50 mM	0.0512 mL	0.2559 mL	0.5117 mL	1.2793 mL
	60 mM	0.0426 mL	0.2132 mL	0.4264 mL	1.0661 mL
	80 mM	0.0320 mL	0.1599 mL	0.3198 mL	0.7996 mL
	100 mM	0.0256 mL	0.1279 mL	0.2559 mL	0.6396 mL