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Cat. No.: HY-N11989

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Nanangenine B

Nanangenine B is a sesquiterpenoid, which can be isolated from Aspergillus nanangensis. Nanangenine B exhibits cytotixicity in cancer cell NS-1 with an IC₅₀ of 38 μg/mL.

For research use only. We do not sell to patients.

CAS No.: 1609469-72-8
Formula: C₂₁H₃₂O₆
Molecular Weight:380.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Nanangenine B Chemical Structure

CAS No.: 1609469-72-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Nanangenine B is a sesquiterpenoid, which can be isolated from Aspergillus nanangensis. Nanangenine B exhibits cytotixicity in cancer cell NS-1 with an IC₅₀ of 38 μg/mL^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
DLD-1	IC₅₀	49 μM Compound: 2	Inhibition of TNF-alpha/IFN-gamma/IL-1beta-induced human CXCL10 (972 bp) promoter activity expressed in human DLD1 cells after 24 hrs by IRSE-driven luciferase reporter assay Inhibition of TNF-alpha/IFN-gamma/IL-1beta-induced human CXCL10 (972 bp) promoter activity expressed in human DLD1 cells after 24 hrs by IRSE-driven luciferase reporter assay	[PMID: 24792812]
DLD-1	IC₅₀	50.7 μM Compound: 2	Inhibition of Stat1 (unknown origin)-induced human CXCL10 (972 bp) promoter activity expressed in TNF-alpha/IFN-gamma/IL-1beta-stimulated human DLD1 cells after 24 hrs by luciferase reporter assay Inhibition of Stat1 (unknown origin)-induced human CXCL10 (972 bp) promoter activity expressed in TNF-alpha/IFN-gamma/IL-1beta-stimulated human DLD1 cells after 24 hrs by luciferase reporter assay	[PMID: 24792812]
DLD-1	IC₅₀	55 μM Compound: 2	Inhibition of TNF-alpha/IFN-gamma/IL-1beta-induced human CXCL10 (972 bp) promoter activity expressed in human DLD1 cells after 24 hrs by luciferase reporter assay Inhibition of TNF-alpha/IFN-gamma/IL-1beta-induced human CXCL10 (972 bp) promoter activity expressed in human DLD1 cells after 24 hrs by luciferase reporter assay	[PMID: 24792812]
DLD-1	IC₅₀	68.4 μM Compound: 2	Inhibition of NF-kappaB (unknown origin)-induced human CXCL10 (972 bp) promoter activity expressed in TNF-alpha/IFN-gamma/IL-1beta-stimulated human DLD1 cells after 24 hrs by luciferase reporter assay Inhibition of NF-kappaB (unknown origin)-induced human CXCL10 (972 bp) promoter activity expressed in TNF-alpha/IFN-gamma/IL-1beta-stimulated human DLD1 cells after 24 hrs by luciferase reporter assay	[PMID: 24792812]

Chemical Information

CAS No. 1609469-72-8
Molecular Weight 380.48
Formula C₂₁H₃₂O₆
SMILES

C[C@]12[C@@](C(C)(CC[C@H]2O)C)([H])[C@@H](C=C3[C@@]1(C(OC3)=O)O)OC(CCCCC)=O
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
- Microorganisms
Aspergillus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lacey HJ, et al., Nanangenines: drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensis. Beilstein J Org Chem. 2019 Nov 5;15:2631-2643. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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