2. PROTAC
  3. PROTAC Linkers
  4. NH2-PEG5-C6-Cl hydrochloride

NH2-PEG5-C6-Cl hydrochloride 

Cat. No.: HY-129622A Purity: ≥98.0%
COA Handling Instructions

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NH2-PEG5-C6-Cl hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

NH2-PEG5-C6-Cl hydrochloride Chemical Structure

NH2-PEG5-C6-Cl hydrochloride Chemical Structure

CAS No. : 2241669-16-7

Size Price Stock Quantity
50 mg USD 45 In-stock
100 mg USD 75 In-stock
250 mg USD 150 In-stock
500 mg   Get quote  
1 g   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of NH2-PEG5-C6-Cl hydrochloride:

NH2-PEG5-C6-Cl hydrochloride Related Antibodies

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Description

NH2-PEG5-C6-Cl hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NH2-PEG5-C6-Cl hydrochloride Related Antibodies
Molecular Weight

392.36

Formula

C16H35Cl2NO5
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

NCCOCCOCCOCCOCCOCCCCCCCl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (637.17 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5487 mL 12.7434 mL 25.4868 mL
5 mM 0.5097 mL 2.5487 mL 5.0974 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (239 KB) HNMR (272 KB) MS (178 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5487 mL 12.7434 mL 25.4868 mL 63.7170 mL
5 mM 0.5097 mL 2.5487 mL 5.0974 mL 12.7434 mL
10 mM 0.2549 mL 1.2743 mL 2.5487 mL 6.3717 mL
15 mM 0.1699 mL 0.8496 mL 1.6991 mL 4.2478 mL
20 mM 0.1274 mL 0.6372 mL 1.2743 mL 3.1858 mL
25 mM 0.1019 mL 0.5097 mL 1.0195 mL 2.5487 mL
30 mM 0.0850 mL 0.4248 mL 0.8496 mL 2.1239 mL
40 mM 0.0637 mL 0.3186 mL 0.6372 mL 1.5929 mL
50 mM 0.0510 mL 0.2549 mL 0.5097 mL 1.2743 mL
60 mM 0.0425 mL 0.2124 mL 0.4248 mL 1.0619 mL
80 mM 0.0319 mL 0.1593 mL 0.3186 mL 0.7965 mL
100 mM 0.0255 mL 0.1274 mL 0.2549 mL 0.6372 mL
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NH2-PEG5-C6-Cl hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NH2-PEG5-C6-Cl2241669-16-7PROTAC LinkersInhibitorinhibitorinhibit

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