1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. Nitro-PDS-Tubulysin M

Nitro-PDS-Tubulysin M 

Cat. No.: HY-128896
Handling Instructions

Nitro-PDS-Tubulysin M is a drug-linker conjugate for ADC with potent antitumor activity by using Tubulysin M (a tubulin polymerization inhibitor), linked via the ADC linker Nitro-PDS.

For research use only. We do not sell to patients.

Nitro-PDS-Tubulysin M Chemical Structure

Nitro-PDS-Tubulysin M Chemical Structure

CAS No. : 1941168-69-9

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Description

Nitro-PDS-Tubulysin M is a drug-linker conjugate for ADC with potent antitumor activity by using Tubulysin M (a tubulin polymerization inhibitor), linked via the ADC linker Nitro-PDS.

IC50 & Target

Auristatin

 

In Vitro

ADC2-2 (anti-CD22 10F4v3 LC K149C Nitro-PDS-Tubulysin M) displays target-specific killing in WSU-DLCL2 human diffuse large B-cell lymphoma tumors with IC50 of 0.147 nM, and ADC2-1 (anti-Napi2b 10H1.11.4B LC K149C Nitro-PDS-Tubulysin M) displays target-specific killing in human ovarian cancer IGROV-1 and OVCAR-3x2.1 with IC50s of 2.07 nM, 1.004 nM, respectively[1].

Molecular Weight

1106.40

Formula

C₅₄H₇₃N₈O₁₁S₃

CAS No.

1941168-69-9

SMILES

O=C(O)[[email protected]@H](C)C[[email protected]@H](NC(C1=CSC([[email protected]](OC(C)=O)C[[email protected]@H](N(C)C([[email protected]@H](NC([[email protected]@H]2[N+](CC3=CC=C(NC(OC[[email protected]](SSC4=CC=C([N+]([O-])=O)N=C4)C)=O)C=C3)(C)CCCC2)=O)[[email protected]@H](C)CC)=O)C(C)C)=N1)=O)CC5=CC=CC=C5

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Nitro-PDS-Tubulysin M
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