CAPG - capping actin protein, gelsolin like Gene

Also Known as MCP; AFCP; HEL-S-66

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 822

About CAPG

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:85,391,602-85,419,540 (from NCBI)

This gene has 15 transcripts (splice variants), 211 orthologues and 7 paralogues. Broad expression in lung (RPKM 44.7), esophagus (RPKM 37.5) and 22 other tissues.

Summary

This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012]

CAPG Products (6)

mRNA Protein Name
NM_001256139.2 NP_001243068.1 macrophage-capping protein isoform 1
NM_001256140.2 NP_001243069.1 macrophage-capping protein isoform 2
NM_001320732.2 NP_001307661.1 macrophage-capping protein isoform 1
NM_001320733.2 NP_001307662.1 macrophage-capping protein isoform 1
NM_001320734.2 NP_001307663.1 macrophage-capping protein isoform 3
NM_001747.4 NP_001738.2 macrophage-capping protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18266911 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
18266911 GOA
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
18266911 GOA
Biological Process GO Annotation Evidence References Source
NOT involved in extracellular matrix disassembly IMP
IMP: Inferred from mutant phenotype
24236012 GOA
NOT involved in positive regulation of podosome assembly IMP
IMP: Inferred from mutant phenotype
24236012 GOA
Cellular Component GO Annotation Evidence References Source
located in Flemming body IDA
IDA: Inferred from direct assay
19166812 GOA
located in centriole IDA
IDA: Inferred from direct assay
19166812 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
18266911 GOA
located in mitotic spindle IDA
IDA: Inferred from direct assay
19166812 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
18938132 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
18938132 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18266911 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

macrophage-capping protein

  • actin-regulatory protein CAP-G

CAPG Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CAPG P40121 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
CAPG P40121 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
CAPG P40121 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CAPG Proteins

Cat. No. Product Name Accession Purity
HY-P75601 CAPG Protein, Human AAH14549 (M1-K348) ≥ 95%, as determined by reducing SDS-PAGE.

CAPG Antibodies

Cat. No. Product Name Application Reactivity
HY-P82731 Actin Regulatory Protein CAPG Antibody (YA2476) WB Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01882 CAPG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09068 NCAPG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19121 Capg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25611 Capg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CAPG VGNC VGNC:26739
Canis familiaris CAPG VGNC VGNC:38697
Macaca mulatta CAPG VGNC VGNC:70528
Rattus norvegicus CAPG RGD RGD:1311724
Felis catus CAPG VGNC VGNC:80045
Mus musculus CAPG MGD MGI:1098259
Others CAPG NCBI