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Cat. No.: HY-108975

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OK-1035

OK-1035 is a selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC₅₀ of 100 μM.

For research use only. We do not sell to patients.

CAS No.: 98293-88-0
Formula: C₁₂H₉N₅O
Molecular Weight:239.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

OK-1035 Chemical Structure

CAS No.: 98293-88-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

OK-1035 is a selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC₅₀ of 100 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	100 μM Compound: 3 (OK-1035)	Inhibition of DNA-dependent protein kinase (DNA-PK) of HeLa cell nuclear cell extract Inhibition of DNA-dependent protein kinase (DNA-PK) of HeLa cell nuclear cell extract	[PMID: 11597411]

In Vitro

OK-1035 (100 μM) is devoid of inhibitory activity against PI 3-kinase and ATM at a concentration of 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 98293-88-0
Molecular Weight 239.23
Formula C₁₂H₉N₅O
SMILES

N#CC1=CC(C2=CC=NC=C2)=C(NC1=O)/C=N/N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Stockley M, et al. Synthesis, crystal structure determination, and biological properties of the DNA-dependent protein kinase (DNA-PK) inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035). Bioorg Med Chem Lett. 2001;11(21):2837-2841. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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