DETA NONOate
Based on 11 publication(s) in Google Scholar
DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor. DETA NONOate shows a slow release normal amounts of NO and long-acting.
For research use only. We do not sell to patients.
- Purity : 98.10%
- CAS No.: 146724-94-9
- Formula: C4H13N5O2
- Molecular Weight:163.18
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Storage:
-80°C
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) DETA NONOate
More- Nature. 2025 Sep;645(8079):244-253. [Abstract]
- Cancer Cell. 2024 Jun 10;42(6):1032-1050.e10. [Abstract]
- Adv Sci (Weinh). 2024 Jul;11(28):e2401269. [Abstract]
- Int J Biol Macromol. 2024 Apr 4;267(Pt 1):131409. [Abstract]
- J Med Chem. 2025 Sep 25;68(18):19781-19790. [Abstract]
- Emerg Microbes Infect. 2026 Dec;15(1):2693364.
- Virulence. 2026 Dec;17(1):2654293. [Abstract]
- Eur J Pharmacol. 2025 Nov 5:1006:178190. [Abstract]
- Acad Radiol. 2025 Jul;32(7):4121-4133. [Abstract]
- J Cell Mol Med. 2024 Nov;28(21):e70203. [Abstract]
- bioRxiv. 2026 Apr 1:2026.03.31.715625. [Abstract]
Customer Validation & Images
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Cell Migration/Invasion Assay
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Bio/Physico-chemical Assay
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RT-PCR
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RT-PCR
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IP
Biological Activity
Description
In Vitro
DETA NONOate (100 μM; 16 h) induces growth in an Mycobacterium abscessus complex (MABC) R morphotype by reduced glycopeptidolipid (GPL) expression of M. abscessus subspecies abscessus (Mab)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
DETA NONOate (1 µM) reduces ischemia- or ischemia/reperfusion-induced injury to cardiac mitochondria and prevents apoptotic cell death[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats (Sixty-two, male, 200-250 g)[2]
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Dosage:15 or 150 μg per rat
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Administration:i.c.v., once
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Result:Accelerated the nociception in a dose-dependent manner, and this acceleration was completely abolished by Methylene Blue (HY-14536).
Chemical Information
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CAS No. 146724-94-9
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Appearance Solid
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Molecular Weight 163.18
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Formula C4H13N5O2
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Color White to off-white
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SMILES
O=NN(O)N(CCN)CCN
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Synonyms
Diethylamine NONOate; NOC-18
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Shipping
Shipping with dry ice.
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Storage
-80°C
* The compound is unstable in solutions, freshly prepared is recommended.
Publications (11)
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Journal Impact Factor
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Most Recent
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Nature
2025 Sep;645(8079):244-253. PMID: 40562926
DETA NONOate purchased from MedChemExpress. Usage Cited in: Nature. 2025 Sep;645(8079):244-253. [Abstract]
NO donor DETA NONOate (100 μM) restored NO activity and substantially improved motility of BMDC.
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Cancer Cell
Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeutic efficacy. [Abstract]2024 Jun 10;42(6):1032-1050.e10. PMID: 38759656 -
Adv Sci (Weinh)
Hydrogen Therapy Reverses Cancer-Associated Fibroblasts Phenotypes and Remodels Stromal Microenvironment to Stimulate Systematic Anti-Tumor Immunity. [Abstract]2024 Jul;11(28):e2401269. PMID: 38757665
DETA NONOate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Jul;11(28):e2401269. [Abstract]
mRNA levels of CAF markers, pro-tumor factors, and immune-modulatory factors were analyzed by qPCR in the CAFs with hydrogen treatment followed by DETA NONOate (DETA/NO) (100–500 μM) treatment.
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Int J Biol Macromol
Chitosan-based hybrid nanospheres for vessel normalization towards enhancing tumor chemotherapy. [Abstract]2024 Apr 4;267(Pt 1):131409. PMID: 38582478 -
J Med Chem
Discovery of a Novel COS/H2S-Donor Hybridized sGC Stimulator for Alleviating Isoproterenol-Induced Myocardial Fibrosis. [Abstract]2025 Sep 25;68(18):19781-19790. PMID: 40934896 -
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Virulence
Phosphorylation of a novel STK substrate SstP1 links SUF Fe-S cluster biogenesis to oxidative stress resistance and virulence in Streptococcus suis. [Abstract]2026 Dec;17(1):2654293. PMID: 41984734 -
Eur J Pharmacol
HEC95468, a novel soluble guanylate cyclase stimulator, shows protection in the Dahl model of cardiorenal disorder. [Abstract]2025 Nov 5:1006:178190. PMID: 40998191
DETA NONOate purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2025 Nov 5:1006:178190. [Abstract]
The NO donor DETA NONOate (DETA-NO) (100 μM; 30 min) synergistically enhanced the ability of HEC95468 to stimulate cGMP production in CHO-Kl-Rat sGC cells, with an EC50 of 0.133 μM.
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Acad Radiol
Ultrasound-Stimulated Microbubbles Cavitation Combined with Nitric Oxide Signaling Pathway to Alleviate Tumor Hypoperfusion and Hypoxia in MC38 Tumor Model. [Abstract]2025 Jul;32(7):4121-4133. PMID: 40234163 -
J Cell Mol Med
Nitric oxide facilitates the S-nitrosylation and deubiquitination of Notch1 protein to maintain cancer stem cells in human NSCLC. [Abstract]2024 Nov;28(21):e70203. PMID: 39523215
DETA NONOate purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2024 Nov;28(21):e70203. [Abstract]
DETA NONOate (20 μM; 24 h) significantly upregulated PROM1, ALDH1, POU5F1 and SOX2 mRNA expressions in non-CSCs.
DETA NONOate purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2024 Nov;28(21):e70203. [Abstract]
DETA NONOate (20 μM) induced S-nitrosylation of Notch1 and elevated binding of Notch1 to UCHL1 in CSCs.
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bioRxiv
2026 Apr 1:2026.03.31.715625. PMID: 41959463
Solvent & Solubility
In Vitro:
H2O : 50 mg/mL (306.41 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Soichiro Sonoda, et al. Exogenous nitric oxide stimulates the odontogenic differentiation of rat dental pulp stem cells. Sci Rep. 2018 Feb 21;8(1):3419. [Content Brief]
[2]. S Shibuta, et al. A new nitric oxide donor, NOC-18, exhibits a nociceptive effect in the rat formalin model. EJ Neurol Sci. 1996 Sep 15;141(1-2):1-5 [Content Brief]
[3]. Nandanwar N, et al. Growth medium and nitric oxide alter Mycobacterium abscessus morphotype and virulence. Microbiol Res. 2021 Dec;253:126887. [Content Brief]
[4]. Umbrasas D, et al. Nitric Oxide Donor NOC-18-Induced Changes of Mitochondrial Phosphoproteome in Rat Cardiac Ischemia Model. Medicina (Kaunas). 2019 Sep 24;55(10):631. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.1282 mL | 30.6410 mL | 61.2820 mL | 153.2051 mL |
| 5 mM | 1.2256 mL | 6.1282 mL | 12.2564 mL | 30.6410 mL | |
| 10 mM | 0.6128 mL | 3.0641 mL | 6.1282 mL | 15.3205 mL | |
| 15 mM | 0.4085 mL | 2.0427 mL | 4.0855 mL | 10.2137 mL | |
| 20 mM | 0.3064 mL | 1.5321 mL | 3.0641 mL | 7.6603 mL | |
| 25 mM | 0.2451 mL | 1.2256 mL | 2.4513 mL | 6.1282 mL | |
| 30 mM | 0.2043 mL | 1.0214 mL | 2.0427 mL | 5.1068 mL | |
| 40 mM | 0.1532 mL | 0.7660 mL | 1.5321 mL | 3.8301 mL | |
| 50 mM | 0.1226 mL | 0.6128 mL | 1.2256 mL | 3.0641 mL | |
| 60 mM | 0.1021 mL | 0.5107 mL | 1.0214 mL | 2.5534 mL | |
| 80 mM | 0.0766 mL | 0.3830 mL | 0.7660 mL | 1.9151 mL | |
| 100 mM | 0.0613 mL | 0.3064 mL | 0.6128 mL | 1.5321 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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