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Cat. No.: HY-103090A

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NPS ALX Compound 4a dihydrochloride

NPS ALX Compound 4a dihydrochloride is a potent and selective 5-hydroxytryptamine₆ (5-HT₆) receptor antagonist, with an IC₅₀ of 7.2 nM and a K_i of 0.2 nM.

For research use only. We do not sell to patients.

CAS No.: 1781934-44-8
Formula: C₂₅H₂₇Cl₂N₃O₂S
Molecular Weight:504.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

NPS ALX Compound 4a dihydrochloride Chemical Structure

CAS No.: 1781934-44-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

NPS ALX Compound 4a dihydrochloride is a potent and selective 5-hydroxytryptamine₆ (5-HT₆) receptor antagonist, with an IC₅₀ of 7.2 nM and a K_i of 0.2 nM^[1].

IC₅₀ & Target^[1]

5-HT₆ Receptor

7.2 nM (IC₅₀)

5-HT₆ Receptor

0.2 nM (Ki)

All 5-HT Receptor Isoforms :

Chemical Information

CAS No. 1781934-44-8
Molecular Weight 504.47
Formula C₂₅H₂₇Cl₂N₃O₂S
SMILES

O=S(N1C=CC2=C1C=C(N3CC(CCC4)N4CC3)C=C2)(C5=C6C=CC=CC6=CC=C5)=O.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Isaac M, et al. 6-Bicyclopiperazinyl-1-arylsulfonylindoles and 6-bicyclopiperidinyl-1-arylsulfonylindolesderivatives as novel, potent, and selective 5-HT6 receptor antagonists. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1719-21. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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NPS ALX Compound 4a dihydrochloride

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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NPS ALX Compound 4a dihydrochloride

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

NPS ALX Compound 4a dihydrochloride Related Classifications

HY-103090A Related Classifications

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