Nrf2 activator-7
Nrf2 activator-7 (Compound 12b) is a potent Nrf2 activator and significantly activates the Nrf2 signaling pathway.
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- CAS No.: 2456295-39-7
- Formule: C35H32N2O11S2
- Masse moléculaire:720.77
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
The binding activity of Nrf2 activator-7 to Keap1 has an IC50 value of 85 nM by fluorescence polarization (FP) assay, an IC50 value of 13.1 nM by time-resolved fluorescence energy transfer (TR-FRET) assay, and a Ki value of 4.9 nM[1].
Nrf2 activator-7 (1, 10, 100 μM; 24 h) increases in the transcription of Nrf2 target genes (GSTM3, HMOX1 and NQO1)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NCM460D cells
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Concentration:1, 10, 100 μM
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Incubation Time:24 h
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Result:Significantly increased transcription of Nrf2 target genes (GSTM3, HMOX1 and NQO1) at 100 μM.
Chemical Information
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CAS No. 2456295-39-7
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Masse moléculaire 720.77
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Formule C35H32N2O11S2
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SMILES
COC1=CC=C(C=C1)C2=C(C3=C(C(N(S(=O)(C4=CC=C(C=C4)OC)=O)CC(O)=O)=C2)C=CC=C3)N(S(=O)(C5=CC=C(C=C5)OC)=O)CC(O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nrf2 activator-7 Related Classifications
HY-149244 Related Classifications
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