country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-189822

Copy Link Print Information

Nrf2 ligand-3

Nrf2 ligand-3 (Compound 11) is an Nrf2 ligand with an A51-derived scaffold. Nrf2 ligand-3 can serve as a PROTAC target protein ligand for the synthesis of L013 (HY-210438).

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 2680526-02-5
Fòrmula: C₂₁H₂₇ClN₆
Peso molecular:398.93

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

Nrf2 ligand-3 Chemical Structure

No. CAS: 2680526-02-5

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Nrf2 ligand-3 (Compound 11) is an Nrf2 ligand with an A51-derived scaffold. Nrf2 ligand-3 can serve as a PROTAC target protein ligand for the synthesis of L013 (HY-210438)^[1].

IC₅₀ & Target

^[1]

Nrf2

In Vitro

PROTAC, short for proteolysis-targeting chimeras, is a heterobifunctional small-molecule compound containing two different ligands: one is a ubiquitin ligase E3 ligand, and the other is a ligand that binds to the target protein in cells. The two ligands are connected by a linker, thereby forming a "ternary" polymer-target protein ligand-Linker-E3 ligand. PROTACs specifically degrade target proteins through the "ubiquitin-proteasome" pathway by bringing the target protein and the intracellular E3 ubiquitin ligase into close proximity. PROTACs can improve the druggability of "undruggable" targets.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2680526-02-5
Peso molecular 398.93
Fòrmula C₂₁H₂₇ClN₆
SMILES

CN(N=C1)C(CC2CC2)=C1C3=NC(N[C@H](CC4)CC[C@@H]4NCC#C)=NC=C3Cl
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Yu X, et al. L013 promotes NRF2 degradation in NRFA-subtype esophageal squamous cell carcinoma. Cell reports. Medicine. 2026 Sep 11.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto