1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. NS3623

NS3623 

Cat. No.: HY-108586
Handling Instructions

NS3623 is an activator of human ether-a-go-go-related gene (hERG1/KV11.1) potassium channels. NS3623 activates the IKr and Ito currents and has antiarrhythmic effect. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels.

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NS3623 Chemical Structure

NS3623 Chemical Structure

CAS No. : 343630-41-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 470 In-stock
Estimated Time of Arrival: December 31
5 mg USD 500 In-stock
Estimated Time of Arrival: December 31
10 mg USD 860 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

NS3623 is an activator of human ether-a-go-go-related gene (hERG1/KV11.1) potassium channels. NS3623 activates the IKr and Ito currents and has antiarrhythmic effect. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels[1][2][3].

In Vitro

In isolated canine cardiomyocytes, application of NS3623 (5 μM) greatly increases the size of the tail current confirming previous studies demonstrating this drug increased IKr. The effect of NS3623 on IKr recorded from cells kept in culture is evaluated. After 48 h, the magnitude of IKr is greatly reduced compared to freshly isolated cells. Peak IKr tail currents are 0.47 ± 0.08 pA/pF in freshly isolated myocytes and 0.28 ± 0.06 pA/pF in 2 day cultured myocytes. Application of NS3623 increases IKr in cultured Mid cells. Analysis of the current-voltage (I-V) relation of IKr tail current showed that NS3623 increased current density in both 1 day and 2 day cultured Mid cells. On a percentage basis, NS3623 increases IKr tail currents (at +50 mV activating pulse) by 60% in normal Mid cells, and 68% in 48 h cultured cells[3].

In Vivo

NS3623 (30 mg/kg; i.v.; lasting for 3 minutes) shortens the corrected QT interval by 25 +/- 4% in anaesthetized guinea pigs[1].
NS3623 (50 mg/kg) shortenes the QT interval by 30 +/- 6% in conscious guinea pigs. NS3623 (50 mg/kg) immediately decreases the QTcF interval and remains significantly shortened for approximately 30 minutes[1].

Animal Model: Anesthetized guinea pig[1]
Dosage: 30 mg/kg
Administration: Intravenous injection; lasting for 3 minutes
Result: Shortened the corrected QT interval by 25 +/- 4%.
Molecular Weight

427.18

Formula

C₁₅H₁₀BrF₃N₆O

CAS No.

343630-41-1

SMILES

O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(Br)C=C2C3=NNN=N3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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Keywords:

NS3623NS 3623NS-3623Potassium ChannelKcsAPotassiumionchannelscurrentQTAntiarrhythmiceffectcaninecardiomyocytesmidmyocardialcellsInhibitorinhibitorinhibit

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NS3623
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