ACT-007
ACT-007 is an indolocarbazole alkaloid derived from Actinomadura sp., which selectively inhibits the proliferation of lung cancer cells and induces G2/M phase cell cycle arrest in breast cancer cells. ACT-007 can be applied in the research of lung cancer and breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 866554-59-8
- Formula: C28H22N4O4
- Molecular Weight:478.50
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MV4-11 | IC50 |
> 1000 nM
|
Antiproliferative activity against human acute myeloid leukemia MV4-11 cells assessed by CCK-8 assay.
Antiproliferative activity against human acute myeloid leukemia MV4-11 cells assessed by CCK-8 assay.
|
42565614 |
| MCF7 | IC50 |
> 1000 nM
|
Antiproliferative activity against human breast cancer MCF-7 cells assessed by CCK-8 assay.
Antiproliferative activity against human breast cancer MCF-7 cells assessed by CCK-8 assay.
|
42565614 |
| MKN-45 | IC50 |
> 1000 nM
|
Antiproliferative activity against human gastric cancer MKN-45 cells assessed by CCK-8 assay.
Antiproliferative activity against human gastric cancer MKN-45 cells assessed by CCK-8 assay.
|
42565614 |
| HCT-116 | IC50 |
> 1000 nM
|
Antiproliferative activity against human colorectal cancer HCT-116 cells assessed by CCK-8 assay.
Antiproliferative activity against human colorectal cancer HCT-116 cells assessed by CCK-8 assay.
|
42565614 |
| 5637 | IC50 |
> 1000 nM
|
Antiproliferative activity against human bladder carcinoma 5637 cells assessed by CCK-8 assay.
Antiproliferative activity against human bladder carcinoma 5637 cells assessed by CCK-8 assay.
|
42565614 |
In Vitro
ACT-007 (compound 2) induces cell cycle arrest at the G2/M phase in temperature-sensitive mouse breast cancer tsFT210 cells[1].
ACT-007 selectively inhibits the proliferation of human lung cancer A549 cells[1].
ACT-007 does not exhibit significant antiproliferative activity against human acute myeloid leukemia MV4-11 cells, human breast cancer MCF-7 cells, human gastric cancer MKN-45 cells, human colorectal cancer HCT-116 cells, and human bladder cancer 5637 cells, with its IC50 value exceeding 1000 nM[1].
ACT-007 (0.0001-10 μM; 48 h) exhibits no antiproliferative activity against HCT-116, 5637, MKN-45, MV-4-11, or MCF-7 human cancer cell lines, with IC50 values > 1000 nM across all tested cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HCT-116, 5637, MKN-45, MV-4-11, MCF-7
-
Concentration:0.0001, 0.001, 0.01, 0.1, 1, 5, 10 μM
-
Incubation Time:48 h
-
Result:Showed no antiproliferative activity against all tested human cancer cell lines, with IC50 values greater than 1000 nM for HCT-116, 5637, MKN-45, MV-4-11, and MCF-7 cells.
Chemical Information
-
CAS No. 866554-59-8
-
Molecular Weight 478.50
-
Formula C28H22N4O4
-
SMILES
O=C1NCC2=C1C3=C4C5=C2C6=CC=CC=C6N5[C@@](C)(O7)[C@H](OC(N8C)=O)[C@H]8C[C@@H]7N4C9=C3C=CC=C9
-
Synonyms
ZHD 0501
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ACT-007 Related Classifications
HY-189002 Related Classifications
Powered by Bioz