Chemokine & Receptors
Human CXCR4 mRNA encodes the human C-X-C motif chemokine receptor 4 (CXCR4) protein, a CXC chemokine receptor specific for stromal cell-derived factor-1. CXCR4 acts with the CD4 protein to support HIV entry into cells.
Human CXCR5 mRNA encodes the human C-X-C motif chemokine receptor 5 (CXCR5) protein, a multi-pass membrane protein that belongs to the CXC chemokine receptor family. CXCR5 is involved in B-cell migration into B-cell follicles of spleen and Peyer patches.
Human CXCR6 mRNA encodes the human C-X-C motif chemokine receptor 6 (CXCR6) protein, a G protein-coupled receptor that belongs to the CXC chemokine receptor family. CXCR6 and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver, spleen red pulp, intestine, lungs, and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells.
Human FGF10 mRNA encodes the human fibroblast growth factor 10 (FGF10) protein, a member of the fibroblast growth factor (FGF) family. FGF10 exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7.
Human FGF2 mRNA encodes the human fibroblast growth factor 2 (FGF2) protein, a member of the fibroblast growth factor (FGF) family. FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth.
Human XCR1 mRNA encodes the human X-C motif chemokine receptor 1 (XCR1) protein, a G protein-coupled receptor that belongs to the CXC chemokine receptor family. XCR1 can transduce a signal by increasing the intracellular calcium ions level.
