Targeted Strategy

a12Dab4 is a peptide ionizable lipid (PIL) used in lipid nanoparticle (LNP) formulations for targeted delivery of mRNA to the liver.

Ale-a12K2 is a peptide-based ionizable lipid modified with bone-binding alendronate. Ale-a12K2 mediates targeted delivery of mRNA to bone tissues. Ale-a12K2 increases mRNA expression levels in the femur and tibia.

a12k4E-Ca is a C-terminal glutamate-modified peptidogenic ionizable lipid that can be used for the preparation of lipid nanoparticles (LNPs). a12k4E-Ca preferentially accumulates in the spleen in vivo, acts as a carrier to mediate spleen-selective mRNA delivery, and enables spleen-specific Cre recombinase-mediated gene editing. a12k4E-Ca restores serum biochemical parameters and cytokines/chemokines. a12k4E-Ca can be used in studies related to LNP preparation.

FO-32 is an ionizable lipid and mRNA delivery carrier with state-of-the-art aerosolized mRNA delivery capability. FO-32 delivers mRNA to mouse muscle, nasal mucosa, lung, as well as ferret lung epithelium (including conducting airways). FO-32 can be used in studies related to the generation of lipid nanoparticles (LNPs) and the optimization of drug delivery.