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Cat. No.: HY-185977

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a12Dab4

a12Dab4 is a peptide ionizable lipid (PIL) used in lipid nanoparticle (LNP) formulations for targeted delivery of mRNA to the liver.

For research use only. We do not sell to patients.

CAS No.: 3113145-01-7
Formula: C₁₁₄H₂₂₉N₉O₅
Molecular Weight:1806.10

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

a12Dab4 Chemical Structure

CAS No.: 3113145-01-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

a12Dab4 is a peptide ionizable lipid (PIL) used in lipid nanoparticle (LNP) formulations for targeted delivery of mRNA to the liver^[1].

In Vivo

a12Dab4 enables organ-specific prime editing in mouse liver through co-delivery of PEmax mRNA and engineered prime editing guide RNAs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3113145-01-7
Molecular Weight 1806.10
Formula C₁₁₄H₂₂₉N₉O₅
SMILES

CC(N[C@H](C(N[C@@H](CCN(CCCCCCCCCCCC)CCCCCCCCCCCC)C(N[C@@H](CCN(CCCCCCCCCCCC)CCCCCCCCCCCC)C(N[C@@H](CCN(CCCCCCCCCCCC)CCCCCCCCCCCC)C(N)=O)=O)=O)=O)CCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lin Y, et al. Tissue-specific mRNA delivery and prime editing with peptide-ionizable lipid nanoparticles. Nature materials. 2026 Jan;25(1):133-145. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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