P2X7 receptor antagonist-2
Based on 1 publication(s) in Google Scholar
P2X7 receptor antagonist-2 is a potent P2X7 receptor antagonist with a pIC50 value of 6.5-7.5. P2X7 receptor antagonist-2 has efficacy of combating neuroinflammation.
For research use only. We do not sell to patients.
- Purity: 98.95%
- CAS No.: 851269-75-5
- Formula: C19H18Cl2N2O2
- Molecular Weight:377.26
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
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Publications Citing Use of MedChemExpress (MCE) P2X7 receptor antagonist-2
MoreAll P2X Receptor Isoforms
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Biological Activity
pIC50：6.5-7.5 (P2X7 receptor)[1]
Chemical Information
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CAS No. 851269-75-5
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Appearance Oil
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Molecular Weight 377.26
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Formula C19H18Cl2N2O2
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Color Colorless to light yellow
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SMILES
ClC1=CC(Cl)=C(CNC(C2CN(C(C2)=O)CC3=CC=CC=C3)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 100 mg/mL (265.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.63 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6507 mL | 13.2535 mL | 26.5069 mL | 66.2673 mL |
| 5 mM | 0.5301 mL | 2.6507 mL | 5.3014 mL | 13.2535 mL | |
| 10 mM | 0.2651 mL | 1.3253 mL | 2.6507 mL | 6.6267 mL | |
| 15 mM | 0.1767 mL | 0.8836 mL | 1.7671 mL | 4.4178 mL | |
| 20 mM | 0.1325 mL | 0.6627 mL | 1.3253 mL | 3.3134 mL | |
| 25 mM | 0.1060 mL | 0.5301 mL | 1.0603 mL | 2.6507 mL | |
| 30 mM | 0.0884 mL | 0.4418 mL | 0.8836 mL | 2.2089 mL | |
| 40 mM | 0.0663 mL | 0.3313 mL | 0.6627 mL | 1.6567 mL | |
| 50 mM | 0.0530 mL | 0.2651 mL | 0.5301 mL | 1.3253 mL | |
| 60 mM | 0.0442 mL | 0.2209 mL | 0.4418 mL | 1.1045 mL | |
| 80 mM | 0.0331 mL | 0.1657 mL | 0.3313 mL | 0.8283 mL | |
| 100 mM | 0.0265 mL | 0.1325 mL | 0.2651 mL | 0.6627 mL |
P2X7 receptor antagonist-2 Related Classifications
HY-150059 Related Classifications
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