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Cat. No.: HY-162951

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P2X7 receptor antagonist-5

P2X7 receptor antagonist-5 (compund 13a) is a potent, orally active and long-lasting P2X7 receptor antagonist.

For research use only. We do not sell to patients.

CAS No.: 3046388-16-0
Formula: C₂₁H₁₇F₃N₆O₃S₂
Molecular Weight:522.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

P2X7 receptor antagonist-5 Chemical Structure

CAS No.: 3046388-16-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

P2X7 receptor antagonist-5 (compund 13a) is a potent, orally active and long-lasting P2X7 receptor antagonist^[1].

IC₅₀ & Target

P2X7^[1]

All P2X Receptor Isoforms :

Chemical Information

CAS No. 3046388-16-0
Molecular Weight 522.52
Formula C₂₁H₁₇F₃N₆O₃S₂
SMILES

C[C@H](NC(C1=CN=C(S1)C2=CC=C(C=C2)S(=O)(C)=O)=O)C3=CN(N=N3)C4=CC(C(F)(F)F)=CC=N4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wenzel B, et al. Targeting cyclic nucleotide phosphodiesterase 5 (PDE5) in brain: Toward the development of a PET radioligand labeled with fluorine-18. Bioorg Chem. 2019 May;86:346-362. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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P2X7 receptor antagonist-5

All P2X Receptor Isoforms