PAD3-IN-1 

PAD3-IN-1 (compound 14b) is an inhibitor of protein arginine deiminase (PAD) and is more than 10-fold more selective for PAD3 than PAD 1, 2, and 4. The IC₅₀ values ​​of PAD3-IN-1 for PAD 1, 2, 3, and 4 are 120, 27.5, 4.5, and 30.5 μM, respectively. And PAD3 is a PAD isoform associated with neurodegenerative responses to spinal cord injury, and PAD3-IN-1 could be used to study PAD-related neurological diseases^[1].

IC50: 120 μM (PAD1)^[1].
IC50: 27.5 μM (PAD2)^[1].
IC50: 4.5 μM (PAD3)^[1].
IC50: 30.5 μM (PAD4)^[1].

433.33

C₂₁H₂₂Cl₂N₄O₂

1671088-84-8

N=C(NCCCC(C(N1CC2=CC(C3=CC=CC=C3Cl)=CC=C2)=O)NC1=O)CCl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jamali H, et al. Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment method. J Am Chem Soc. 2015 Mar 18;137(10):3616-21.  [Content Brief]