PAD3-IN-1
PAD3-IN-1 (compound 14b) is an inhibitor of protein arginine deiminase (PAD) and is more than 10-fold more selective for PAD3 than PAD 1, 2, and 4. The IC50 values of PAD3-IN-1 for PAD 1, 2, 3, and 4 are 120, 27.5, 4.5, and 30.5 μM, respectively. And PAD3 is a PAD isoform associated with neurodegenerative responses to spinal cord injury, and PAD3-IN-1 could be used to study PAD-related neurological diseases.
For research use only. We do not sell to patients.
- CAS No.: 1671088-84-8
- Formula: C21H22Cl2N4O2
- Molecular Weight:433.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: 120 μM (PAD1)[1]. IC50: 27.5 μM (PAD2)[1]. IC50: 4.5 μM (PAD3)[1]. IC50: 30.5 μM (PAD4)[1].
Chemical Information
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CAS No. 1671088-84-8
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Molecular Weight 433.33
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Formula C21H22Cl2N4O2
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SMILES
N=C(NCCCC(C(N1CC2=CC(C3=CC=CC=C3Cl)=CC=C2)=O)NC1=O)CCl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PAD3-IN-1 Related Classifications
HY-139088 Related Classifications
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