PD-1/PD-L1-IN-26
PD-1/PD-L1-IN-26 (Compound II-14) is a potent inhibitor of PD-1/PD-L1 with an IC50 of 0.0380 μM. PD-1/PD-L1-IN-26 activates the immune microenvironment by promoting the infiltration of CD4+ T cells into tumor tissues. PD-1/PD-L1-IN-26 has the potential for the research of cancer diseases.
For research use only. We do not sell to patients.
- CAS No.: 2966090-78-6
- Formula: C43H52N4O8
- Molecular Weight:752.89
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CT26 | IC50 |
19.84 μM
Compound: II-14
|
Antiproliferative activity against mouse CT26 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against mouse CT26 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 34481337] |
Chemical Information
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CAS No. 2966090-78-6
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Molecular Weight 752.89
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Formula C43H52N4O8
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SMILES
CC1=C(C=CC=C1C2=CC=CC(OCCCN3CCC(CC3)CO)=C2)COC4=CC=C(C(OCC5=NN=C(O5)C6=CC=CC=C6)=C4)CNC(CO)(CO)CO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)