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Cat. No.: HY-163958

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PD-L1-IN-7

PD-L1-IN-7 (compound CB31) is an inhibitor of PD-L1, which can induce PD-L1 internalization and PD-L1 retention in cells. PD-L1-IN-7 can inhibit the interaction of PD-1/PD-L1 (IC₅₀: 0.2 nM), change the glycosylation pattern, and promote PD-L1 degradation. PD-L1-IN-7 can also enhance T cell infiltration, amplify T cell function and the ability to kill tumor cells.

For research use only. We do not sell to patients.

CAS No.: 3024733-03-4
Formula: C₄₆H₅₀N₆O₇
Molecular Weight:798.93

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PD-L1-IN-7 Chemical Structure

CAS No.: 3024733-03-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 0.2 nM (PD-1/PD-L1)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	CC₅₀	>10 μM Compound: CB31	Cytotoxicity against CHO-K1 cells expressing PD-L1 incubated for 8 hrs by CellTiter 96 AQueous One Solution assay Cytotoxicity against CHO-K1 cells expressing PD-L1 incubated for 8 hrs by CellTiter 96 AQueous One Solution assay	[PMID: 39111015]
HEK-293T	CC₅₀	>30 μM Compound: CB31	Cytotoxicity against HEK293T cells upto 50 uM incubated for 24 hrs by MTT assay Cytotoxicity against HEK293T cells upto 50 uM incubated for 24 hrs by MTT assay	[PMID: 39111015]
HepG2	CC₅₀	16 μM Compound: CB31	Cytotoxicity against human HepG2 cells upto 50 uM incubated for 24 hrs by MTT assay Cytotoxicity against human HepG2 cells upto 50 uM incubated for 24 hrs by MTT assay	[PMID: 39111015]
Jurkat	CC₅₀	>10 μM Compound: CB31	Cytotoxicity against human Jurkat cells expressing NFAT incubated for 6 hrs by CellTiter 96 AQueous One Solution assay Cytotoxicity against human Jurkat cells expressing NFAT incubated for 6 hrs by CellTiter 96 AQueous One Solution assay	[PMID: 39111015]
Jurkat	EC₅₀	15 nM Compound: CB31	Inhibition of interaction of human PD-1 expressed in human Jurkat T cells co-expressing Luc/human PD-L1 expressed in CHO-K1 cells assessed as activation of NFAT-mediated luciferase activity pretreated compound with CHO-K1 cells for 2 hrs followed by co-tr Inhibition of interaction of human PD-1 expressed in human Jurkat T cells co-expressing Luc/human PD-L1 expressed in CHO-K1 cells assessed as activation of NFAT-mediated luciferase activity pretreated compound with CHO-K1 cells for 2 hrs followed by co-tr	[PMID: 39111015]
MOLT-4	CC₅₀	16 μM Compound: CB31	Cytotoxicity against human MOLT-4 cells by CellTiter 96 AQueous One Solution assay Cytotoxicity against human MOLT-4 cells by CellTiter 96 AQueous One Solution assay	[PMID: 39111015]
T-cell	EC₅₀	13 nM Compound: CB31	Induction of immune function in CD3/CD28-activated human T cells co-cultured with CHO cells expressing PD-L1 assessed as IFN-gamma secretion incubated for 72 hrs by ELISA Induction of immune function in CD3/CD28-activated human T cells co-cultured with CHO cells expressing PD-L1 assessed as IFN-gamma secretion incubated for 72 hrs by ELISA	[PMID: 39111015]
T-cell	EC₅₀	9 nM Compound: CB31	Induction of immune function in CD3/CD28-activated human T cells co-cultured with CHO cells expressing PD-L1 assessed as IL-2 secretion incubated for 72 hrs by ELISA Induction of immune function in CD3/CD28-activated human T cells co-cultured with CHO cells expressing PD-L1 assessed as IL-2 secretion incubated for 72 hrs by ELISA	[PMID: 39111015]

Chemical Information

CAS No. 3024733-03-4
Molecular Weight 798.93
Formula C₄₆H₅₀N₆O₇
SMILES

CC1=C(C=CC=C1C2=NC3=CC(CN([C@@H]4CC[C@H](CC4)C(O)=O)C)=CC(C#N)=C3O2)C5=C6C(N(C7=CC(OC)=C(C(OC)=C7)CN([C@H]8[C@H](COCC8)O)C)N=C6)=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Design, synthesis, and optimization of novel PD-L1 inhibitors and the identification of a highly potent and orally bioavailable PD-L1 inhibitor

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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