2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. PD-L1-IN-7

PD-L1-IN-7 (compound CB31) is an inhibitor of PD-L1, which can induce PD-L1 internalization and PD-L1 retention in cells. PD-L1-IN-7 can inhibit the interaction of PD-1/PD-L1 (IC50: 0.2 nM), change the glycosylation pattern, and promote PD-L1 degradation. PD-L1-IN-7 can also enhance T cell infiltration, amplify T cell function and the ability to kill tumor cells.

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PD-L1-IN-7

PD-L1-IN-7 Chemical Structure

CAS No. : 3024733-03-4

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PD-L1-IN-7 Related Antibodies

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Description

PD-L1-IN-7 (compound CB31) is an inhibitor of PD-L1, which can induce PD-L1 internalization and PD-L1 retention in cells. PD-L1-IN-7 can inhibit the interaction of PD-1/PD-L1 (IC50: 0.2 nM), change the glycosylation pattern, and promote PD-L1 degradation. PD-L1-IN-7 can also enhance T cell infiltration, amplify T cell function and the ability to kill tumor cells[1].

IC50 & Target

IC50: 0.2 nM (PD-1/PD-L1)[1]
Cellular Effect
Cell Line Type Value Description References
CHO-K1 CC50
> 10 μM
Compound: CB31
Cytotoxicity against CHO-K1 cells expressing PD-L1 incubated for 8 hrs by CellTiter 96 AQueous One Solution assay
Cytotoxicity against CHO-K1 cells expressing PD-L1 incubated for 8 hrs by CellTiter 96 AQueous One Solution assay
[PMID: 39111015]
HEK-293T CC50
> 30 μM
Compound: CB31
Cytotoxicity against HEK293T cells upto 50 uM incubated for 24 hrs by MTT assay
Cytotoxicity against HEK293T cells upto 50 uM incubated for 24 hrs by MTT assay
[PMID: 39111015]
HepG2 CC50
16 μM
Compound: CB31
Cytotoxicity against human HepG2 cells upto 50 uM incubated for 24 hrs by MTT assay
Cytotoxicity against human HepG2 cells upto 50 uM incubated for 24 hrs by MTT assay
[PMID: 39111015]
Jurkat CC50
> 10 μM
Compound: CB31
Cytotoxicity against human Jurkat cells expressing NFAT incubated for 6 hrs by CellTiter 96 AQueous One Solution assay
Cytotoxicity against human Jurkat cells expressing NFAT incubated for 6 hrs by CellTiter 96 AQueous One Solution assay
[PMID: 39111015]
Jurkat EC50
15 nM
Compound: CB31
Inhibition of interaction of human PD-1 expressed in human Jurkat T cells co-expressing Luc/human PD-L1 expressed in CHO-K1 cells assessed as activation of NFAT-mediated luciferase activity pretreated compound with CHO-K1 cells for 2 hrs followed by co-treatment with human Jurkat T cells for 6 hrs by Bio-Glo Luciferase assay
Inhibition of interaction of human PD-1 expressed in human Jurkat T cells co-expressing Luc/human PD-L1 expressed in CHO-K1 cells assessed as activation of NFAT-mediated luciferase activity pretreated compound with CHO-K1 cells for 2 hrs followed by co-treatment with human Jurkat T cells for 6 hrs by Bio-Glo Luciferase assay
[PMID: 39111015]
MOLT-4 CC50
16 μM
Compound: CB31
Cytotoxicity against human MOLT-4 cells by CellTiter 96 AQueous One Solution assay
Cytotoxicity against human MOLT-4 cells by CellTiter 96 AQueous One Solution assay
[PMID: 39111015]
T-cell EC50
13 nM
Compound: CB31
Induction of immune function in CD3/CD28-activated human T cells co-cultured with CHO cells expressing PD-L1 assessed as IFN-gamma secretion incubated for 72 hrs by ELISA
Induction of immune function in CD3/CD28-activated human T cells co-cultured with CHO cells expressing PD-L1 assessed as IFN-gamma secretion incubated for 72 hrs by ELISA
[PMID: 39111015]
T-cell EC50
9 nM
Compound: CB31
Induction of immune function in CD3/CD28-activated human T cells co-cultured with CHO cells expressing PD-L1 assessed as IL-2 secretion incubated for 72 hrs by ELISA
Induction of immune function in CD3/CD28-activated human T cells co-cultured with CHO cells expressing PD-L1 assessed as IL-2 secretion incubated for 72 hrs by ELISA
[PMID: 39111015]
Molecular Weight

798.93

Formula

C46H50N6O7
CAS No.
SMILES

CC1=C(C=CC=C1C2=NC3=CC(CN([C@@H]4CC[C@H](CC4)C(O)=O)C)=CC(C#N)=C3O2)C5=C6C(N(C7=CC(OC)=C(C(OC)=C7)CN([C@H]8[C@H](COCC8)O)C)N=C6)=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PD-L1-IN-7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-L1-IN-73024733-03-4PD-1/PD-L1PD-1/Programmed death-ligand 1Inhibitorinhibitorinhibit

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