Pentapeptide-3
Based on 1 Customer Validation
Pentapeptide-3 is a multifunctional anti-aging cosmeceutical peptide and Acetylcholine Receptor antagonist that induces muscle relaxation by antagonizing acetylcholine receptors and mimics enkephalin to exert botulinum-like activity. Pentapeptide-3 can be used in research on skin aging and wrinkles.
For research use only. We do not sell to patients.
- Purity : 99.83%
- CAS No.: 135679-88-8
- Formula: C21H37N9O5
- Molecular Weight:495.58
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Pentapeptide-3 exhibits strong binding affinity to TGF-β receptor-1 with a docking score of -8.12 kcal/mol and forms key hydrogen bonds with ASP290, HIS283, TYR282, TYR249, and ILE211[1].
Pentapeptide-3 interacts with TNF-α with a docking score of -6.12 kcal/mol and forms a hydrogen bond with TYR151[1].
Pentapeptide-3 binds to AKT-1 with a docking score of -7.38 kcal/mol and forms hydrogen bonds with ASP292, ASN279, and GLU234[1].
Pentapeptide-3 exhibits strong binding affinity with MAPK14, with a docking score of -8.25 kcal/mol, and forms hydrogen bonds with LEU171, GLY170, LYS53, and TYR35[1].
Pentapeptide-3, a pentapeptide derived from snake venom (H-Gly-Pro-Arg-Pro-Ala-NH2), acts as an ACh receptor antagonist, blocking neural function and preventing unwanted muscle spasms[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 135679-88-8
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Appearance Solid
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Molecular Weight 495.58
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Formula C21H37N9O5
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Color White to off-white
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Sequence
Gly-Pro-Arg-Pro-Ala-NH2
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Sequence Shortening
GPRPA-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (201.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[2]. Errante F, et al. Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy. Frontiers in chemistry. 2020;8:572923. [Content Brief]
[3]. Zhang L, et al. Cosmeceuticals and peptides. Clin Dermatol. 2009 Sep-Oct;27(5):485-94. [Content Brief]
[4]. He Q, et al. Bioactive oligopeptides and the application in skin regeneration and rejuvenation. Journal of applied biomaterials & functional materials. 2025;23:22808000251330974. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0178 mL | 10.0892 mL | 20.1784 mL | 50.4459 mL |
| 5 mM | 0.4036 mL | 2.0178 mL | 4.0357 mL | 10.0892 mL | |
| 10 mM | 0.2018 mL | 1.0089 mL | 2.0178 mL | 5.0446 mL | |
| 15 mM | 0.1345 mL | 0.6726 mL | 1.3452 mL | 3.3631 mL | |
| 20 mM | 0.1009 mL | 0.5045 mL | 1.0089 mL | 2.5223 mL | |
| 25 mM | 0.0807 mL | 0.4036 mL | 0.8071 mL | 2.0178 mL | |
| 30 mM | 0.0673 mL | 0.3363 mL | 0.6726 mL | 1.6815 mL | |
| 40 mM | 0.0504 mL | 0.2522 mL | 0.5045 mL | 1.2611 mL | |
| 50 mM | 0.0404 mL | 0.2018 mL | 0.4036 mL | 1.0089 mL | |
| 60 mM | 0.0336 mL | 0.1682 mL | 0.3363 mL | 0.8408 mL | |
| 80 mM | 0.0252 mL | 0.1261 mL | 0.2522 mL | 0.6306 mL | |
| 100 mM | 0.0202 mL | 0.1009 mL | 0.2018 mL | 0.5045 mL |
Pentapeptide-3 Related Classifications
HY-P0099 Related Classifications
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