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Cat. No.: HY-P5500

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Peptide P1

Peptide P1 is a histidine- and isoleucine-rich peptide segment (HHHHHHIIKIIK). Peptide P1 undergoes gas-phase proton exchange with co-infused bulk solvent in the StepWave ion guide, manifesting as deuterium loss and peak broadening of the deuterated peptide envelope, which can be mitigated by adjusting the StepWave settings. Peptide P1 is commonly used as an ETD scrambling standard and as a synthetic infusion peptide standard for H/D exchange mass spectrometry.

For research use only. We do not sell to patients.

CAS No.: 959780-73-5
Formula: C₇₂H₁₁₂N₂₆O₁₃
Molecular Weight:1549.83

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Peptide P1 Chemical Structure

CAS No.: 959780-73-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Peptide P1 (2 mg/mL) exhibits gas-phase deuterium loss within the StepWave ion guide after injection into the Synapt G2-Si, resulting in broadening of the deuterated envelope at higher charge states, whereas optimizing the StepWave settings mitigates this effect^[1].
Peptide P1 (HHHHHHIIKIIK) is analyzed by H/D exchange mass spectrometry as an infused peptide, and the deuterated mass spectra are recorded in Figure S5^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 959780-73-5
Molecular Weight 1549.83
Formula C₇₂H₁₁₂N₂₆O₁₃
Sequence

His-His-His-His-His-His-Ile-Ile-Lys-Ile-Ile-Lys
Sequence Shortening

HHHHHHIIKIIK
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Guttman M, et al. Tuning a High Transmission Ion Guide to Prevent Gas-Phase Proton Exchange During H/D Exchange MS Analysis. Journal of the American Society for Mass Spectrometry. 2016 Apr;27(4):662-8.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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