Self-assembling Peptides

RAD-KLT is a self-assembling peptide. RAD-KLT significantly enhances endothelial cell survival, proliferation, migration, and morphological tubulogenesis. RAD-KLT can be used for tissue regeneration research.

CREKA-YpFFK(Nph) is a gold nanoparticle surface ligand composed of CREKA and YPFFK (Nph), responsible for tumor targeting and alkaline phosphatase-responsive bond cleavage, respectively. CREKA-YpFFK(Nph) can be used for tumor targeting research.

RAD-FHR peptide is a self-assembling peptide. RAD-FHR peptide significantly enhances migration, proliferation and growth factor-secretion ability in human adipose stem cells (hASCs). RAD-FHR peptide can be used for synthesis of nanofiber hydrogel for stem cell behaviors research in biomimetic 3D systems.

AcfffGk is a short peptide with the ability to self-assemble into helical nanofibers, forming non-covalently cross-linked hydrogels that serve as scaffolds for 3D cell culture.

d-KYFIL is a peptide-based biomaterial that can be used for stereocomplexation and can be used to study the regulation of supramolecular assembly of hydrogel biomaterials.

Peptide K is a self-assembling peptide fiber that can be used to prepare fibrous nanocomposite hydrogels. The fibrous nanocomposite hydrogels have a dynamic network that adapts to cells and enhances cell-matrix and cell-cell interactions, thus significantly promoting the mechanotransduction, metabolic energy, and osteogenesis of encapsulated stem cells.

TFE-IDAtp1-LinA is a highly potent amphiphilic carrier, containing a trifluoroethyl-iminodiacetic acid analog of Stp. TFE-IDAtp1-LinA, formed nanoparticles with Cas9 RNP/ssDNA, achieved enhanced green fluorescent protein knockouts with an ED₅₀ of 0.38 nM Cas9/sgRNA ribonucleoproteins (RNP).

PTZ-GFFY is a super-gelator that can form a hydrogel at the ultra-low concentration.

Fmoc-KCRGDK is a self-assembling peptide that can be used to prepare hydrogels and assist in drug delivery for immune checkpoint inhibitors. Fmoc-KCRGDK can be applied in cancer immunotherapy research.

Nap-GFFY, a naphthylacetic acid modifi ed tetrapeptide of GFFY, is a self-assembling fiber peptide.

SAF-p1 is a self-assembling fiber peptide that can form sticky-ended heterodimers by assembling with SAF-p2 (HY-P10703) through complementary amino acid sequences. These heterodimers further self-assemble into long-chain fiber structures. SAF-p1 is promising for the development of nanomaterials in the biomedical field .

SAF-p2 is a self-assembling fiber peptide that can form sticky-ended heterodimers by assembling with SAF-p2 (HY-P10702) through complementary amino acid sequences. These heterodimers further self-assemble into long-chain fiber structures. SAF-p2 is promising for the development of nanomaterials in the biomedical field .

Q11 peptide is a β-sheet-forming peptide that plays an important role in self-assembly and targeted applications. As a scaffold peptide, Q11 peptide can display immunogenic epitopes and is widely used in peptide-based immune vaccine research. Additionally, Q11 peptide can be conjugated with MUC1 glycopeptides for the study of self-assembling, adjuvant-free MUC1 glycopeptide vaccines. Q11 peptide holds great potential for research in the field of cancer immunology.

NDI-Lyso is a lysosome-targeted anticancer agent that induces the formation of rigid long fibers in cancer cell lysosomes through an enzyme-instructed self-assembly (EISA) mechanism catalyzed by cathepsin B. This process triggers lysosomal swelling, membrane permeabilization (LMP), and membrane disruption, ultimately leading to cancer cell apoptosis via a non-classical caspase-independent pathway. NDI-Lyso exhibits significant selective anticancer activity in various cancer cell lines and drug-resistant cancer cells (IC₅₀ ~10 μM) while showing low toxicity to normal cells (IC₅₀ > 60 μM).

L-KYFIL is a pentapeptide that is amorphous on its own. When mixed with D-KYFIL, it transforms from fibrous hydrogels into plate-like networks, resulting in changes in mechanical properties and forming a crystalline state. The mixture can protect L-KYFIL from proteolytic degradation. L-KYFIL can be used to study stereocomplexation behavior of peptide sequences and in the development of biomaterials.

KGFRWR is a short peptide sequence, belonging to self-assembling peptides (SAPs), which can self-assemble into functional nanostructures, typically nanofibers, under physiological conditions. KGFRWR can be used to target tumor cells and tumor vasculature, exhibiting antitumor activity.

Self-assembling peptide pY1 is a peptide that assemblies around cancer cells and targets EGFR. When co-cultured with Ovalbumin (OVA), pY1 can effectively block the endocytosis of OVA.

Ac-ILVAGK-NH2 is a self-assembling peptide that helps human H1 embryonic stem cells maintain their pluripotency.

MAX8 is a synthetic β-hairpin peptide that folds rapidly and self-assembles into a β-sheet-rich fibrous hydrogel network via non-covalent crosslinking. MAX8 hydrogel exhibits excellent shear-thinning and self-healing properties, enabling precise delivery via syringe and maintaining local retention after implantation. MAX8 hydrogel can uniformly encapsulate cells while preserving their viability and morphology, and protect growth factors (e.g., NGF) and chemotherapeutic drugs from degradation. MAX8 is applicable for spinal cord injury repair, medulloblastoma treatment, and three-dimensional high-throughput drug screening.

R5 peptide shows silica-precipitating activity and can be isolated from Cylindrotheca fusiformis.