PF-06671008

PF-06671008 is a bispecific CD3/P-cadherin binding agent (K_d 11.4, 0.47 nM). PF-06671008 binds to the T cell receptor complex, activates polyclonal T cells, and forms a trimolecular complex that redirects T cells to P-cadherin-expressing tumor cells. PF-06671008 elicits P-cadherin-dependent T cell cytotoxicity across multiple indications. PF-06671008 causes increased tumor-infiltrating T cells in mice, achieves higher tumor exposure in PBMC-engrafted versus non-PBMC-engrafted mice by reducing internalization of P-cadherin-bound drug, and induces T cell-mediated tumor killing, elevated serum cytokines, tumor regression, as well as prolonged half-life and maintained exposure in tumor-bearing mice. PF-06671008 can be used in the research of solid tumors^[1][2].