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Cat. No.: HY-164412

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Phosphatidylcholine (C18:2,C20:4)

Phosphatidylcholine (C18:2,C20:4) is a phosphatidylcholine species containing linoleic acid (C18:2) and arachidonic acid (C20:4) as fatty acid components, that can be isolated from egg yolk, red blood cell membranes of rat, rabbit, human, and dog. Phosphatidylcholine (C18:2,C20:4) can be used as a biomarker for the research of Alzheimer's disease.

For research use only. We do not sell to patients.

CAS No.: 85082-02-6
Formula: C₄₆H₈₀NO₈P
Molecular Weight:806.10

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

Phosphatidylcholine (C18:2,C20:4) Chemical Structure

CAS No.: 85082-02-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

In Vivo

Phosphatidylcholine (C18:2,C20:4) is an endogenous lipid biomarker whose serum levels are significantly reduced in Aβ_1-42-induced AD rats and are restored toward normal by treatment with Rhodiola crenulata extract^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 85082-02-6
Molecular Weight 806.10
Formula C₄₆H₈₀NO₈P
SMILES

CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(O[C@H](COC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sun W, Liu C, Zhou X, et al.. Serum lipidomics study reveals protective effects of Rhodiola crenulata extract on Alzheimer's disease rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Nov 20;1158:122346. [Content Brief]

[2]. Doğru Pekiner, et al. FATTY ACID COMPOSITION OF RED BLOOD CELL MEMBRANE PHOSPHATIDYLETHANOLAMINE AND PHOSPHATIDYLCHOLINE IN RAT, RABBIT, HUMAN AND DOG. 2002. Journal of Faculty of Pharmacy of Ankara University, 31(3), 169-182.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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