2. PI3K/Akt/mTOR
  3. PI3K
  4. PI3Kδ-IN-15

PI3Kδ-IN-15 (compound 6b) is a selective PI3Kδ inhibitor with an IC50 of 0.5 nM for p110δ. PI3Kδ-IN-15 inhibits PI3Kδ with >30-fold higher potency than PI3Kγ, PI3Kβ, and PI3Kα.

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PI3Kδ-IN-15 Chemical Structure

PI3Kδ-IN-15 Chemical Structure

CAS No. : 870281-17-7

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PI3Kδ-IN-15 Related Antibodies

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Description

PI3Kδ-IN-15 (compound 6b) is a selective PI3Kδ inhibitor with an IC50 of 0.5 nM for p110δ. PI3Kδ-IN-15 inhibits PI3Kδ with >30-fold higher potency than PI3Kγ, PI3Kβ, and PI3Kα[1].

IC50 & Target[1]

p110δ

0.5 nM (IC50)

p110γ

15.3 nM (IC50)

p110β

145 nM (IC50)

p110α

152 nM (IC50)

Molecular Weight

401.40

Formula

C21H16FN7O
CAS No.
SMILES

O=C1N(C2=CC=CC=C2)C([C@@H](NC3=C4N=CNC4=NC=N3)C)=NC5=C1C(F)=CC=C5
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Purity & Documentation
References
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PI3Kδ-IN-15 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3Kδ-IN-15870281-17-7PI3KPhosphoinositide 3-kinasePI3Kδ inhibitorhematologic malignanciesInhibitorinhibitorinhibit

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